ArticleGenetics2015
A novel paradigm for nonassociative long-term memory in Drosophila: predator-induced changes in oviposition behavior.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory inProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Multigenerational inheritance of parasitic stress memory inEnvironmental epigenetics · 2025Article
- Defensive tactics: lessons from Drosophila.Biology open · 2024Review
- Oviposition experience affects oviposition preference iniScience · 2024Article
- Diverse memory paradigms inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Evaluating Learning and Memory in Drosophila melanogaster to Study the Neurodevelopmental Impacts of Toxicants.Current protocols · 2022Article
- Review
- Neuropeptide F signaling regulates parasitoid-specific germline development and egg-laying in Drosophila.PLoS genetics · 2021Article
- The Panopticon-Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference.Frontiers in behavioral neuroscience · 2021Article
- Social competition stimulates cognitive performance in a sex-specific manner.Proceedings. Biological sciences · 2020Article
- Behavioral and environmental contributions to drosophilid social networks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- -2019 PLOS Genetics Research Prize: Fruit fly school - language and dialects for communicating a threat.PLoS genetics · 2019Article
- NewG3 (Bethesda, Md.) · 2019Article
- Neural circuitry of social learning in Drosophila requires multiple inputs to facilitate inter-species communication.Communications biology · 2019Article
- Which protocol reflects more reliable facts about learning and memory in fruit flies?EXCLI journal · 2019Article
- Drosophila species learn dialects through communal living.PLoS genetics · 2018Article
- Predator experience changes spider mites' habitat choice even without current threat.Scientific reports · 2018Article
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Authors and funding
5 authors.
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Abstract
Learning processes in Drosophila have been studied through the use of Pavlovian associative memory tests, and these paradigms have been extremely useful in identifying both genetic factors and neuroanatomical structures that are essential to memory formation. Whether these same genes and brain compartments also contribute to memory formed from nonassociative experiences is not well understood. Exposures to environmental stressors such as predators are known to induce innate behavioral responses and can lead to new memory formation that allows a predator response to persist for days after the predator threat has been removed. Here, we utilize a unique form of nonassociative behavior in Drosophila where female flies detect the presence of endoparasitoid predatory wasps and alter their oviposition behavior to lay eggs in food containing high levels of alcohol. The predator-induced change in fly oviposition preference is maintained for days after wasps are removed, and this persistence in behavior requires a minimum continuous exposure time of 14 hr. Maintenance of this behavior is dependent on multiple long-term memory genes, including orb2, dunce, rutabaga, amnesiac, and Fmr1. Maintenance of the behavior also requires intact synaptic transmission of the mushroom body. Surprisingly, synaptic output from the mushroom body (MB) or the functions of any of these learning and memory genes are not required for the change in behavior when female flies are in constant contact with wasps. This suggests that perception of this predator that leads to an acute change in oviposition behavior is not dependent on the MB or dependent on learning and memory gene functions. Because wasp-induced oviposition behavior can last for days and its maintenance requires a functional MB and the wild-type products of several known learning and memory genes, we suggest that this constitutes a paradigm for a bona fide form of nonassociative long-term memory that is not dependent on associated experiences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.