ArticleJournal of innate immunity2015
Systemic infection generates a local-like immune response of the bacteriome organ in insect symbiosis.
Article in Journal of innate immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results.Journal of the American Heart Association · 2017Trial
- Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- The role of insect gut microbiota in host fitness, detoxification and nutrient supplementation.Antonie van Leeuwenhoek · 2024Review
- Endosymbiont-containing germarium transcriptional survey in a cereal weevil depicts downregulation of immune effectors at the onset of sexual maturity.Frontiers in physiology · 2023Article
- Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system.Microbiome · 2022Article
- Article
- Spätzle Homolog-Mediated Toll-Like Pathway Regulates Innate Immune Responses to Maintain the Homeostasis of Gut Microbiota in the Red Palm Weevil,Frontiers in microbiology · 2020Article
- WeevilProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Tsetse Fly Displays an Attenuated Immune Response to Its Secondary Symbiont,Frontiers in microbiology · 2019Article
- What can a weevil teach a fly, and reciprocally? Interaction of host immune systems with endosymbionts in Glossina and Sitophilus.BMC microbiology · 2018Review
- An IMD-like pathway mediates both endosymbiont control and host immunity in the cereal weevil Sitophilus spp.Microbiome · 2018Article
- Tick Humoral Responses: Marching to the Beat of a Different Drummer.Frontiers in microbiology · 2017Review
- Bacterial cell biology outside the streetlight.Environmental microbiology · 2016Review
- Antimicrobial peptides and cell processes tracking endosymbiont dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Disentangling a Holobiont - Recent Advances and Perspectives inFrontiers in microbiology · 2016Review
- Characterization of Antibacterial Activities of Eastern Subterranean Termite, Reticulitermes flavipes, against Human Pathogens.PloS one · 2016Article
- Weevil endosymbiont dynamics is associated with a clamping of immunity.BMC genomics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endosymbiosis is common in insects thriving in nutritionally unbalanced habitats. The cereal weevil, Sitophilus oryzae, houses Sodalis pierantonius, a Gram-negative intracellular symbiotic bacterium (endosymbiont), within a dedicated organ called a bacteriome. Recent data have shown that the bacteriome expresses certain immune genes that result in local symbiont tolerance and control. Here, we address the question of whether and how the bacteriome responds to insect infections involving exogenous bacteria. We have established an infection model by challenging weevil larvae with the Gram-negative bacterium Dickeya dadantii. We showed that D. dadantii infects host tissues and triggers a systemic immune response. Gene transcript analysis indicated that the bacteriome is also immune responsive, but it expresses immune effector genes to a lesser extent than the systemic and intestinal responses. Most genes putatively involved in immune pathways remain weakly expressed in the bacteriome following D. dadantii infection. Moreover, quantitative PCR experiments showed that the endosymbiont load is not affected by insect infection or the resulting bacteriome immune activation. Thus, the contained immune effector gene expression in the bacteriome may prevent potentially harmful effects of the immune response on endosymbionts, whilst efficiently protecting them from bacterial intruders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.