ArticleJundishapur journal of microbiology2014
Prevalence of Aminoglycoside Resistance Genes in Acinetobacter baumannii Isolates.
Article in Jundishapur journal of microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Changes in Susceptibility Profiles ofJournal of clinical medicine · 2026Article
- Burden and Economic Impact of Antimicrobial Resistance inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Clonal Diversity and Resistome Dynamics ofMedicina (Kaunas, Lithuania) · 2025Article
- Cultivation ofBiology · 2025Article
- Trends of Antibiotic Resistance in ESKAPE Pathogens in Mbarara Regional Referral Hospital (2015-2022), South Western, Uganda.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Guava Leaf Extract Exhibits Antimicrobial Activity in Extensively Drug-Resistant (XDR)Molecules (Basel, Switzerland) · 2024Article
- Carbapenem-resistantiScience · 2024Review
- Factors associated with antibiotic resistance and survival analysis of severe pneumonia patients infected withSAGE open medicine · 2024Article
- Deciphering the Role of WWTPs in Cold Environments as Hotspots for the Dissemination of Antibiotic Resistance Genes.Microbial ecology · 2023Article
- Mobile genetic elements carrying aminoglycoside resistance genes inFrontiers in microbiology · 2023Article
- Detection of theArchives of Razi Institute · 2022Article
- Evaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals.Molecular and cellular pediatrics · 2022Article
- Multidrug-ResistantLife (Basel, Switzerland) · 2021Article
- Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes inInfection and drug resistance · 2021Article
- Characterization of aminoglycoside resistance mechanisms in Acinetobacter Baumannii isolates from burn wound colonization.Annals of burns and fire disasters · 2019Article
- Association of the genes encoding Metallo-β-Lactamase with the presence of integrons among multidrug-resistant clinical isolates ofInfection and drug resistance · 2019Article
- Biofilm Formation and Detection of Fluoroquinolone- and Carbapenem-Resistant Genes in Multidrug-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019Article
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- The Frequency of Antibiotic Resistance and ESBLs Among ClinicallyThe open microbiology journal · 2018Article
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5 authors.
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Abstract
backgroundAcinetobacter baumannii is one of the major causes of nosocomial infections and is resistant to most available antibiotics. Aminoglycosides remain as drugs of choice for treatment of Acinetobacter infections yet resistance to aminoglycosides has increased in the recent years.
objectivesThe present study investigated the prevalence of genes encoding aminoglycoside-modifying enzymes in A. baumannii strains isolated from patients of Tabriz city, northwest of Iran. MATERIALS AND
methodsA total of 103 Acinetobacter isolates were collected from Imam Reza Hospital of Tabriz University of medical sciences. Antimicrobial susceptibility patterns of the isolates to different antimicrobial agents including cephalosporins, gentamicin, amikacin, tobramycin, colistin and polymyxin, were evaluated by the disc diffusion method. The frequency of aminoglycoside modifying enzymes encoding genes aacC1, aphA6, aadA1 and aadB was analyzed by the PCR method.
resultsAntimicrobial susceptibility analysis showed that the highest resistance was towards beta-lactam antibiotics including cephalosporins whereas the highest sensitivity was observed towards colistin (77%) and polymyxin (84%). The resistance rate to aminoglycosides was 81%, 86% and 63% for amikacin, gentamicin and tobramycin, respectively. The PCR results showed that among the 103 A. baumannii isolates, 56 (65.11 %) were positive for aacC1, 52 (60.46 %) for aphA6, 24 (27.9 %) for aadA1 and 16 (18.6 %) for aadB resistant genes.
conclusionsThe results of this study indicated that the genes encoding aminoglycoside-modifying enzymes are prevalent in A. baumannii isolates in the study region, which highlighted the necessity of considering preventive measures to control dissemination of these resistance genes.
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