ReviewDairy science & technology
A review of the biology of calcium phosphate sequestration with special reference to milk.
Review in Dairy science & technology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- pH-responsive ion release kinetics of a chitosan-based hydrogel incorporating nanohydroxyapatite and sodium fluoride for enamel remineralization.BMC oral health · 2026Article
- Nanocrystal-induced chronic tubular-nephropathy in tropical countries: diagnosis, mitigation, and eradication.European journal of medical research · 2023Article
- Impact of Dairy Products and Plant-Based Alternatives on Dental Health: Food Matrix Effects.Nutrients · 2023Review
- On the Application of Calcium Phosphate Micro- and Nanoparticles as Food Additive.Nanomaterials (Basel, Switzerland) · 2022Review
- Calcium Absorption from Food Products: Food Matrix Effects.Nutrients · 2021Review
- The predictive power of saliva electrolytes exceeds that of saliva microbiomes in diagnosing early childhood caries.Journal of oral microbiology · 2021Article
- Got Mylk? The Emerging Role of Australian Plant-Based Milk Alternatives as A Cow's Milk Substitute.Nutrients · 2020Article
- Remineralization of dentin slices using casein phosphopeptide-amorphous calcium phosphate combined with sodium tripolyphosphate.Biomedical engineering online · 2020Article
- Changes in the salivary electrolytic dynamic after sucrose exposure in children with Early Childhood Caries.Scientific reports · 2020Article
- Waiting for Aπαταω: 250 Years Later.Foundations of science · 2019Article
- Biological surface properties in extracellular vesicles and their effect on cargo proteins.Scientific reports · 2019Article
- A quantitative model of the bovine casein micelle: ion equilibria and calcium phosphate sequestration by individual caseins in bovine milk.European biophysics journal : EBJ · 2019Article
- Novel treatment strategies for chronic kidney disease: insights from the animal kingdom.Nature reviews. Nephrology · 2018Review
- Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca.Royal Society open science · 2015Article
- Dynamic footprint of sequestration in the molecular fluctuations of osteopontin.Journal of the Royal Society, Interface · 2015Article
- Calcium orthophosphates (CaPOProgress in biomaterialsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In milk, a stable fluid is formed in which sequestered nanoclusters of calcium phosphate are substructures in casein micelles. As a result, calcium and phosphate concentrations in milk can be far in excess of their solubility. Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes. Caseins evolved from tooth and bone proteins well before the evolution of lactation. It has therefore been suggested that the role of caseins in milk is an adaptation of an antecedent function in the control of some aspect of biomineralisation. There is new evidence that nanocluster-type complexes are also present in blood serum and, by implication, in many other closely related biofluids. Because such fluids are stable but nevertheless supersaturated with respect to the bone and tooth mineral hydroxyapatite, they allow soft and mineralised tissues to co-exist in the same organism with relative ease. An appreciable concentration of nanocluster complexes exists in fresh saliva. Such saliva may stabilise tooth mineral and help to repair demineralised lesions. In the extracellular matrix of bone, nanocluster complexes may be involved in directing the amorphous calcium phosphate to intrafibrillar spaces in collagen where they can mature into oriented apatite crystals. Thus, evidence is accumulating that calcium phosphate sequestration by phosphopeptides to form equilibrium complexes, first observed in milk, is more generally important in the control of physiological calcification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.