ArticleInternational journal of biological sciences2015
Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5.
Article in International journal of biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Systematic Review of Molecular Targeted Therapies for Adult-Type Diffuse Glioma: An Analysis of Clinical and Laboratory Studies.International journal of molecular sciences · 2023Pooled it
- Multicellular Network-Informed Survival Model for Identification of Drug Targets of Gliomas.IEEE journal of biomedical and health informatics · 2025Article
- Molecular Targeted Therapies in Glioblastoma Multiforme: A Systematic Overview of Global Trends and Findings.Brain sciences · 2023Review
- Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.Cells · 2022Article
- LncRNA-H19 gene plays a significant role in regulating glioma cell function.Molecular genetics & genomic medicine · 2021Article
- MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway.Journal of biomedical science · 2021Article
- Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma.Molecular medicine reports · 2020Article
- Prognostic significance of PAK family kinases in acute myeloid leukemia.Cancer gene therapy · 2020Observational
- miR‑489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways.Oncology reports · 2019Article
- DGKζ Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma.International journal of biological sciences · 2019Article
- Correlation between chemotherapy resistance in osteosarcoma patients and PAK5 and Ezrin gene expression.Oncology letters · 2018Article
- P21-activated kinase 7 (PAK7) interacts with and activates Wnt/β-catenin signaling pathway in breast cancer.Journal of Cancer · 2018Article
- High expression of P21-activated kinase 5 protein is associated with poor survival in gastric cancer.Oncology letters · 2017Article
- miR-101 inhibits glioma cell invasion via the downregulation of COX-2.Oncology letters · 2016Article
- Evaluation of hierarchical models for integrative genomic analyses.Bioinformatics (Oxford, England) · 2016Article
- Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioma is the most common type of primary intracranial tumor and is highly lethal due to its pathogenetic location, high invasiveness, and poor prognosis. Even combined surgery and chemoradiotherapy do not effectively rescue glioma patients. Molecular target therapy is considered a safe and promising therapy for glioma. The identification of a novel, effective target protein in gliomas is of great interest. We found that PAK5 was highly expressed in the tumor tissues of glioma patients and human glioma cell lines. We then used a lentivirus-delivered short hairpin RNA to stably silence PAK5 expression in glioma cells and explore its influence. The results showed that the inhibition of PAK5 reduced cell viability and delayed the cell cycle at the G0/G1 phase in the glioma cells with PAK5 high expression. In addition, silencing PAK5 expression in U87 cells weakened their colony formation ability and in vivo tumorigenesis ability. Further studies demonstrated that PAK5 inhibition led to an increase in cleaved caspase 3 and a decrease in β-catenin. In conclusion, our results suggest that the inhibition of PAK5 by RNA interference might efficiently suppress tumor development of glioma cells with PAK5 high expression. This finding provides a novel, promising therapeutic target for glioma treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.