ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Immunity in Rodent Models of Stress.Biological psychiatry · 2026Review
- Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case-Control Study.Journal of clinical laboratory analysis · 2026Article
- The role of gut microbiota in neuropathic pain: insights into immune mechanisms.The journal of headache and pain · 2025Review
- Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research.Molecular psychiatry · 2025Review
- Bidirectional regulation of the brain-gut axis inMicrobiology spectrum · 2025Article
- The association between major depressive disorder and generalized anxiety disorder with hematological indices in the Rafsanjan youth cohort study.Scientific reports · 2025Article
- Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review.Biomolecules · 2025Review
- Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?Current neuropharmacology · 2024Article
- Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study.Frontiers in psychiatry · 2024Article
- B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression.Frontiers in cellular neuroscience · 2024Review
- Social stress induces autoimmune responses against the brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Meningeal T-cells in the cross-talk between memory consolidation and sleep.Neural regeneration research · 2023Article
- Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation.Journal of neuroinflammation · 2023Article
- T cells: an emerging cast of roles in bipolar disorder.Translational psychiatry · 2023Review
- Sex differences in depression: An immunological perspective.Brain research bulletin · 2023Review
- Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses.Nature immunology · 2023Article
- Influence of gut microbiota on resilience and its possible mechanisms.International journal of biological sciences · 2023Review
- Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells.Pharmacological reviews · 2022Review
- Principal component analysis of salivary cytokines and hormones in the acute stress response.Frontiers in psychiatry · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We examined whether cells of the adaptive immune system retain the memory of psychosocial stress and thereby alter mood states and CNS function in the host. Lymphocytes from mice undergoing chronic social defeat stress or from unstressed control mice were isolated and adoptively transferred into naive lymphopenic Rag2(-/-) mice. Changes in affective behavior, hippocampal cell proliferation, microglial activation states, and blood cytokine levels were examined in reconstituted stress-naive mice. The mice receiving lymphocytes from defeated donors showed less anxiety, more social behavior, and increased hippocampal cell proliferation compared with those receiving no cells or cells from unstressed donors. Mice receiving stressed immune cells had reduced pro-inflammatory cytokine levels in the blood relative to the other groups, an effect opposite to the elevated donor pro-inflammatory cytokine profile. Furthermore, mice receiving stressed immune cells had microglia skewed toward an anti-inflammatory, neuroprotective M2-like phenotype, an effect opposite the stressed donors' M1-like pro-inflammatory profile. However, stress had no effect on lymphocyte surface marker profiles in both donor and recipient mice. The data suggest that chronic stress-induced changes in the adaptive immune system, contrary to conferring anxiety and depressive behavior, protect against the deleterious effects of stress. Improvement in affective behavior is potentially mediated by reduced peripheral pro-inflammatory cytokine load, protective microglial activity, and increased hippocampal cell proliferation. The data identify the peripheral adaptive immune system as putatively involved in the mechanisms underlying stress resilience and a potential basis for developing novel rapid-acting antidepressant therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.