ArticleJournal of neurophysiology2015
The superior precentral gyrus of the insula does not appear to be functionally specialized for articulation.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trial
- Mapping of critical prosodic and phonetic networks in post-stroke apraxia of speech.bioRxiv : the preprint server for biology · 2025Article
- Using unsupervised dimensionality reduction to identify lesion patterns predictive of post-stroke aphasia severity.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Article
- Reading reshapes stimulus selectivity in the visual word form area.bioRxiv : the preprint server for biology · 2024Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- Mapping cortical activations underlying covert and overt language production using high-density diffuse optical tomography.NeuroImage · 2023Article
- Spatiotemporally distributed frontotemporal networks for sentence reading.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dissecting structural connectivity of the left and right inferior frontal cortex in children who stutter.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring.NeuroImage. Clinical · 2022Article
- Individual differences in representational similarity of first and second languages in the bilingual brain.Human brain mapping · 2021Article
- Neural Representations of the Voice Tremor Spectrum.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Apraxia of speech involves lesions of dorsal arcuate fasciculus and insula in patients with aphasia.Neurology. Clinical practice · 2020Article
- Article
- Connectivity of the human insula: A cortico-cortical evoked potential (CCEP) study.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Connectivity profiles of the insular network for speech control in healthy individuals and patients with spasmodic dysphonia.Brain structure & function · 2018Article
- Behavioral Effects of Chronic Gray and White Matter Stroke Lesions in a Functionally Defined Connectome for Naming.Neurorehabilitation and neural repair · 2018Article
- Functional Characterization of the Human Speech Articulation Network.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- The neuroanatomy of speech sequencing at the syllable level.PloS one · 2018Article
- Can neuroimaging help aphasia researchers? Addressing generalizability, variability, and interpretability.Cognitive neuropsychology · 2017Article
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5 authors.
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Abstract
Broca (Broca P. Bull Soc Anat Paris 36: 330-357, 1861) influentially argued that posterior left inferior frontal gyrus supports speech articulation. According to an alternative proposal (e.g., Dronkers NF. Nature 384: 159-161, 1996; Wise RJ, Greene J, Buchel C, Scott SK. Lancet 353: 1057-1061, 1999; Baldo JV, Wilkins DP, Ogar J, Willock S, Dronkers NF. Cortex 47: 800-807, 2011), a region in the anterior insula [specifically, the superior precentral gyrus of the insula (SPGI)] is the seat of articulatory abilities. Moreover, Dronkers and colleagues have argued that the SPGI is functionally specialized for (complex) speech articulation. Here, we evaluate this claim using individual-subject functional MRI (fMRI) analyses (e.g., Fedorenko E, Hsieh PJ, Nieto-Castanon A, Whitfield-Gabrieli S, Kanwisher N. J Neurophysiol 104: 1177-1194, 2010). We find that the SPGI responds weakly, if at all, during articulation (parts of Broca's area respond 3-4 times more strongly) and does not show a stronger response to higher articulatory demands. This holds regardless of whether the SPGI is defined functionally (by selecting the most articulation-responsive voxels in the vicinity of the SPGI in each subject individually) or anatomically (by using masks drawn on each individual subject's anatomy). Critically, nonspeech oral movements activate the SPGI more strongly than articulation, especially under the anatomical definition of the SPGI. In line with Hillis et al. (Hillis AE, Work M, Barker PB, Jacobs MA, Breese EL, Maurer K. Brain 127: 1479-1487, 2004; also Trupe L, Varma DD, Gomez Y, Race D, Leigh R, Hillis AE, Gottesman RF. Stroke 44: 740-744, 2013), we argue that previous links between the SPGI, and perhaps anterior insula more generally, and articulation may be due to its high base rate of ischemic damage (and activation in fMRI; Yarkoni T, Poldrack RA, Nichols TE, Van Essen DC, Wager TD. Nat Methods 8: 665-670, 2011), combined with its proximity to regions that more directly support speech articulation, such as the precentral gyrus or the posterior aspects of the inferior frontal gyrus (Richardson JD, Fillmore P, Rorden C, Lapointe LL, Fridriksson J. Brain Lang 123: 125-130, 2012), and thus susceptibility to joint damage.
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