ArticleMolecular biology of the cell2015
Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis.Nature reviews. Cardiology · 2025Review
- SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamics.Life science alliance · 2025Article
- B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor.Science advances · 2024Article
- Positioning centrioles and centrosomes.The Journal of cell biology · 2024Review
- Endolysosomal vesicles at the center of B cell activation.The Journal of cell biology · 2024Review
- Medium-throughput image-based phenotypic siRNA screen to unveil the molecular basis of B cell polarization.Scientific data · 2023Article
- Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells.Cells · 2022Article
- Phenotyping polarization dynamics of immune cells using a lipid droplet-cell pairing microfluidic platform.Cell reports methods · 2022Article
- B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells.Exploration of targeted anti-tumor therapy · 2022Article
- Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse.Frontiers in cell and developmental biology · 2021Article
- B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction.Frontiers in immunology · 2021Article
- The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center.Small GTPases · 2020Article
- The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.The Journal of cell biology · 2019Article
- Actomyosin-driven force patterning controls endocytosis at the immune synapse.Nature communications · 2019Article
- Article
- Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells.Frontiers in immunology · 2019Article
- Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes.Molecular biology of the cell · 2017Article
- B cell antigen extraction is regulated by physical properties of antigen-presenting cells.The Journal of cell biology · 2017Article
- To use or not to use the force: How B lymphocytes extract surface-tethered antigens.The Journal of cell biology · 2017Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for presentation to T-lymphocytes. Antigen internalization and processing rely on the early dynein-dependent transport of BCR-antigen microclusters to the synapse center, as well as on the later polarization of the microtubule-organizing center (MTOC). MTOC repositioning allows the release of proteases and the delivery of MHC class II molecules at the synapse. Whether and how these events are coordinated have not been addressed. Here we show that the ancestral polarity protein Par3 promotes BCR-antigen microcluster gathering, as well as MTOC polarization and lysosome exocytosis, at the synapse by facilitating local dynein recruitment. Par3 is also required for antigen presentation to T-lymphocytes. Par3 therefore emerges as a key molecule in the coupling of the early and late events needed for efficient extraction and processing of immobilized antigen by B-cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.