ArticleNature communications2015
ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 111 citations in OpenAlex.
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- Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.Frontiers in cell and developmental biology · 2026Review
- The role of jasmonates in plant root growth and development.Frontiers in plant science · 2026Review
- Molecular Network Analysis in Model and Non-Model Legumes: Challenges in Omics Data Interpretation Across Species, with a Focus onPlants (Basel, Switzerland) · 2025Review
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- Stem cell quiescence and dormancy in plant meristems.Journal of experimental botany · 2024Review
- A WUSCHEL-related homeobox transcription factor, SlWOX4, negatively regulates drought tolerance in tomato.Plant cell reports · 2024Article
- Genome-Wide Analysis of the WOX Family and Its Expression Pattern in Root Development ofInternational journal of molecular sciences · 2024Article
- The peptidase DA1 cleaves and destabilizes WUSCHEL to control shoot apical meristem size.Nature communications · 2024Article
- Hydrogen Peroxide Signaling in the Maintenance of Plant Root Apical Meristem Activity.Antioxidants (Basel, Switzerland) · 2024Review
- WOX2 functions redundantly with WOX1 and WOX4 to positively regulate seed germination in Arabidopsis.Planta · 2024Article
- Network Analysis of Metabolome and Transcriptome Revealed Regulation of Different Nitrogen Concentrations on Hybrid Poplar Cambium Development.International journal of molecular sciences · 2024Article
- Bioenergy sorghum nodal root bud development: morphometric, transcriptomic and gene regulatory network analysis.Frontiers in plant science · 2024Article
- Functional Modules in the Meristems: "Tinkering" in Action.Plants (Basel, Switzerland) · 2023Review
- Dual regulations of cell cycle regulator DPa by auxin inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A blast from the past: Understanding stem cell specification in plant roots using laser ablation.Quantitative plant biology · 2023Article
- Maintenance of stem cell activity in plant development and stress responses.Frontiers in plant science · 2023Review
- Ectopic expression of WOX5 promotes cytokinin signaling and de novo shoot regeneration.Plant cell reports · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cells that normally express ROW1. The wox5-1/row1-3 double mutants show similar phenotypes to wox5-1 indicating that WOX5 is epistatic to ROW1. ROW1 specifically binds trimethylated histone H3 lysine 4 (H3K4me3) in the WOX5 promoter region to repress its transcription. QC expression of ROW1 results in a wox5-1-like phenotype with undetectable WOX5 transcripts. We propose that ROW1 is essential for QC maintenance and for stem cell niche development through the repression of WOX5 in the proximal meristem.
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