Evidence map›Paper›PMID 25631626›Full record

ReviewJournal of developmental origins of health and disease2015

Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.

M F Hivert, W Perng, S M Watkins, C S Newgard, L C Kenny, B S Kristal, M E Patti, E Isganaitis, D L DeMeo, E Oken and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of developmental origins of health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M F Hivert1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
W Perng1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
S M Watkins3Metabolon Inc.,West Sacramento,CA,USA.
C S Newgard4Nutrition and Metabolism Center,Duke University of Medicine,Durham,NC,USA.
L C Kenny5The Irish Center for Fetal and Neonatal Translational Research,University College Cork,Co. Cork,USA.
B S Kristal6Departments of Neurosurgery,Brigham & Women's Hospital and Harvard Medical School,Boston,MA,USA.
M E Patti7Research Division,Joslin Diabetes Center,Boston,MA,USA.
E Isganaitis7Research Division,Joslin Diabetes Center,Boston,MA,USA.
D L DeMeo8Department of Medicine,Channing Division of Network Medicine and Division of Pulmonary and Critical Care,Brigham and Women's Hospital,Boston,MA,USA.
E Oken1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
M W Gillman1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
Pathways of Mother to Child Transmission of Metabolic RiskR00HD064793 · NICHD · JOSLIN DIABETES CENTER · PI ISGANAITIS, ELVIRA MARIE · 2013 to 2015
$734k
NICHD NIH HHS K24 HD069408NICHD NIH HHS R00 HD064793NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD 034568NICHD NIH HHS R37 HD034568
6 · The paper itself

Abstract

In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.

Indexed as

MetabolomicsAnimalsHumansObesityobesity

Identifiers

PMID25631626
PMCPMC4406410

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.