ReviewEuropean archives of psychiatry and clinical neuroscience2015
Unipolar mania: a necessary diagnostic concept.
Review in European archives of psychiatry and clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence of unipolar mania in bipolar I disorder: a systematic review and meta-analysis of observational studies.Epidemiology and psychiatric sciences · 2026Pooled it
- Characterizing the clinical profile of mania without major depressive episodes: a systematic review and meta-analysis of factors associated with unipolar mania.Psychological medicine · 2023Pooled it
- Unipolar mania as a distinct clinical presentation: Differences in illness course and psychosocial functioning compared with bipolar I disorder.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- The Promise of Long-acting Injectable Antipsychotics for the Treatment of Bipolar I Disorder: The Role of Manic Predominance.Actas espanolas de psiquiatria · 2025Article
- Combining predominant polarity and affective spectrum concepts in bipolar disorder: towards a novel theoretical and clinical perspective.International journal of bipolar disorders · 2024Article
- Prevalence and characteristics of unipolar mania in a low-income country setting: population-based data from the Butajira cohort, rural Ethiopia.Social psychiatry and psychiatric epidemiology · 2023Article
- Bipolar disorder in the International Classification of Diseases-Eleventh version: A review of the changes, their basis, and usefulness.World journal of psychiatry · 2022Review
- The nosological status of unipolar mania and hypomania within UK Biobank according to objective and subjective measures of diurnal rest and activity.Bipolar disorders · 2022Article
- Clinical research diagnostic criteria for bipolar illness (CRDC-BP): rationale and validity.International journal of bipolar disorders · 2022Review
- Review
- Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .Dialogues in clinical neuroscience · 2020Review
- Bipolar disorders in ICD-11: current status and strengths.International journal of bipolar disorders · 2020Article
- A Review on the General Stability of Mood Disorder Diagnoses Along the Lifetime.Current psychiatry reports · 2018Review
- Treatment of Bipolar Disorder in a Lifetime Perspective: Is Lithium Still the Best Choice?Clinical drug investigation · 2017Review
- Circuits Regulating Pleasure and Happiness in Bipolar Disorder.Frontiers in neural circuits · 2017Article
- Will mania survive DSM-5 and ICD-11?International journal of bipolar disorders · 2015Article
- A neuroplastic deafferentation hypothesis for bipolar disorder.Medical hypotheses · 2015Article
- Classification and neurobiological concepts of mania, bipolar disorder and major depression.European archives of psychiatry and clinical neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the classification of mood disorders, major depressive disorder is separate from bipolar disorders whereas mania is not. Studies on pure mania are therefore rare. Our paper reviews the evidence for distinguishing pure mania (M) and mania with mild depression (Md) from bipolar disorder. Two large epidemiological studies found a prevalence of 1.7-1.8% of M/Md in adolescents and adults. Several clinical follow-up studies demonstrated good stability of the diagnosis after a previous history of three manic episodes. Compared to bipolar disorder, manic disorder is characterised by a weaker family history for depression, an earlier onset, fewer recurrences and better remission, and is less comorbid with anxiety disorders. In addition, mania is strongly associated with a hyperthymic temperament, manifests more psychotic symptoms and is more often treated with antipsychotics. Twin and family studies find mania to be more heritable than depression and show no significant transmission from depression to mania or from mania to depression. Cardiovascular mortality is elevated among patients with mood disorders generally and is highest among those with mania. In non-Western countries, mania and the manic episodes in bipolar disorder are reported to occur more frequently than in Western countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.