Evidence map›Paper›PMID 25631608›Full record

ArticleNature communications2015

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, Jennifer A Brody, Marco Dauriz, Marie-France Hivert, Sridharan Raghavan, Leonard Lipovich and 195 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Journal of the American Society of Nephrology : JASN · 2017
    Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

205 authors.

Jennifer Wessel1] Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA [2] Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Audrey Y Chu1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Sara M Willems1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Shuai WangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Jennifer A Brody1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Marco Dauriz1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona Medical School and Hospital Trust of Verona, Verona 37126, Italy.
Marie-France Hivert1] Harvard Pilgrim Health Care Institute, Department of Population Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA [2] Division of Endocrinology and Metabolism, Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1 [3] Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Sridharan Raghavan1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
Leonard Lipovich1] Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA [2] Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48202, USA.
Bertha HidalgoDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Keolu Fox1] Department of Medicine, University of Washington, Seattle, Washington 98195, USA [2] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Jennifer E Huffman1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, Scotland EH4 2XU, UK.
Ping AnDivision of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Yingchang Lu1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Margaret G EhmQuantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA.
Li LiQuantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA.
Abigail S BaldridgeDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio FI-70211, Finland.
Ravinder Abrol1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA.
Céline BesseCEA, Institut de Génomique, Centre National de Génotypage, 2 Rue Gaston Crémieux, EVRY Cedex 91057, France.
Anne BolandCEA, Institut de Génomique, Centre National de Génotypage, 2 Rue Gaston Crémieux, EVRY Cedex 91057, France.
Jette Bork-JensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA.
Daniel F Freitag1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK.
Melissa E GarciaIntramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Kazuo Hara1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Johanna JakobsdottirIcelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland.
Leslie A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Jill C LaytonIndiana University, Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA.
Man LiDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Karina MeidtnerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal DE-14558, Germany.
Alanna C MorrisonHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA.
Marjolein J Peters1] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam 2300 RC, The Netherlands.
Maria Sabater-LlealAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Claudia Schurmann1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Angela SilveiraAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Albert V Smith1] Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland [2] University of Iceland, Reykjavik IS-101, Iceland.
Lorraine Southam1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.
Marcus H StoiberDepartment of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Rona J StrawbridgeAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden.
Kristine H AllinThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Jennifer L AponteQuantitative Sciences, PCPS, GlaxoSmithKline, North Carolina 27709, USA.
Tin Aung1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Caterina BarbieriDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy.
Nathan A Bihlmeyer1] Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Maryland 21205, USA [2] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Cristina BombieriSection of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona 37100, Italy.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Sean M BurnsDiabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Yuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Yii-DerI ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Ching-Yu Cheng1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [4] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Jacek CzajkowskiDivision of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Georg B Ehret1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA [2] Division of Cardiology, Geneva University Hospital Geneva 1211, Switzerland.
Gudny EiriksdottirIcelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland.
Stefan A EscherDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece.
Mattias Frånberg1] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden [2] Department of Numerical Analysis and Computer Science, SciLifeLab, Stockholm University, Stockholm SE-106 91, Sweden.
Giovanni GambaroDivision of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome 00168, Italy.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
William A GoddardMaterials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA.
Anuj GoelDepartment of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Megan L GroveHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA.
Stefan GustafssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala SE-751 85, Sweden.
Yang HaiInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Göran HallmansDepartment of Biobank Research, Umeå University, Umeå SE-901 87, Sweden.
Jiyoung HeoDepartment of Biomedical Technology, Sangmyung University, Chungnam 330-720, Korea.
Per Hoffmann1] Institute of Human Genetics, Department of Genomics, Life &Brain Center, University of Bonn, Bonn DE-53127, Germany [2] Human Genomics Research Group, Division of Medical Genetics, University Hospital Basel Department of Biomedicine 4031, Basel, Switzerland [3] Institute of Neuroscience and Medicine (INM-1) Genomic Imaging Research Center Juelich, Juelich DE-52425, Germany.
Mohammad K Ikram1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Memory Aging &Cognition Centre (MACC), National University Health System, Singapore 117599, Singapore.
Richard A Jensen1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Marit E JørgensenSteno Diabetes Center, Gentofte DK-2820, Denmark.
Torben Jørgensen1] Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup DK-2600, Denmark [2] Faculty of Medicine, University of Aalborg, Aalborg DK-9220, Denmark.
Maria KaraleftheriEchinos Medical Centre, Echinos 67300, Greece.
Chiea C Khor1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
Andrea KirkpatrickMaterials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA.
Aldi T KrajaDivision of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio FI-70211, Finland.
Ethan M Lange1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA [2] Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
I T Lee1] Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan [2] School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Aaron Leong1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jiemin Liao1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Chunyu LiuNational Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Yongmei LiuDepartment of Epidemiology &Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina 27106, USA.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Allan Linneberg1] Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup DK-2600, Denmark [2] Department of Clinical Experimental Research, Copenhagen University Hospital Glostrup, Glostrup DK-2600, Denmark [3] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Giovanni MalerbaSection of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona 37100, Italy.
Vasiliki Mamakou1] National and Kapodistrian University of Athens, Faculty of Medicine, Athens 115 27, Greece [2] Dromokaiteio Psychiatric Hospital, Athens 124 61, Greece.
Eirini MarouliDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece.
Nisa M Maruthur1] Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Angela MatchanThe Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Roberta McKean-CowdinDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA.
Olga McLeodAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Ginger A MetcalfHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Donna M MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Ioanna Ntalla1] Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece [2] University of Leicester, Leicester LE1 7RH, UK.
Nicholette D Palmer1] Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA [2] Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27106, USA.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Andreas Peter1] Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry and Institute of Diabetes Research and Metabolic Diseases, University of Tübingen, Tübingen DE-72076, Germany [2] German Center for Diabetes Research (DZD), Neuherberg DE-85764, Germany.
Nigel W Rayner1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK [3] The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden.
Ken Rice1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Cinzia F SalaDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy.
Bengt Sennblad1] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden [2] Science for Life Laboratory, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Ioannis SerafetinidisDepartment of Gastroenterology, Gennimatas General Hospital, Athens 11527, Greece.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nicole Soranzo1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] Department of Hematology, Long Road, Cambridge CB2 0XY, UK.
Elizabeth K SpeliotesDepartment of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Eli A StahlDivision of Psychiatric Genomics, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Kathleen Stirrups1] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Nikos TentolourisFirst Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens 11527, Greece.
Anastasia ThanopoulouDiabetes Centre, 2nd Department of Internal Medicine, National University of Athens, Hippokration General Hospital, Athens 11527, Greece.
Mina TorresDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA.
Michela TragliaDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy.
Emmanouil TsafantakisAnogia Medical Centre, Anogia 740 51, Greece.
Sundas JavadMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Lisa R YanekThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Eleni Zengini1] Dromokaiteio Psychiatric Hospital, Athens 124 61, Greece [2] University of Sheffield, Sheffield S10 2TN, UK.
Diane M BeckerThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Joshua C Bis1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
James B Brown1] Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA [2] Department of Statistics, University of California at Berkeley, Berkeley, California 94720, USA.
L Adrienne Cupples1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Torben Hansen1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark [2] Faculty of Health Science, University of Copenhagen, Copenhagen 1165, Denmark.
Erik Ingelsson1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala SE-751 85, Sweden [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Andrew J KarterDivision of Research, Kaiser Permanente, Northern California Region, Oakland, California 94612, USA.
Carlos LorenzoDepartment of Medicine, University of Texas Health Science Center, San Antonio, Texas 77030, USA.
Rasika A MathiasThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado 80204, USA.
Gina M Peloso1] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Wayne H-H Sheu1] Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan [2] School of Medicine, National Yang-Ming University, Taipei 112, Taiwan [3] College of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milano 20132, Italy.
Dhananjay VaidyaThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Rohit VarmaDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27106, USA.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrücke, Nuthetal DE-14558, Germany.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens 17671, Greece.
Panos Deloukas1] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK [2] Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK [3] Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 22254, Saudi Arabia.
Ele FerranniniCNR Institute of Clinical Physiology, Pisa 73100, Italy.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Paul W Franks1] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA [3] Department of Public Health &Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Vilmundur Gudnason1] Icelandic Heart Association, Holtasmari 1, Kopavogur IS-201, Iceland [2] University of Iceland, Reykjavik IS-101, Iceland.
Anders HamstenAtherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Tamara B HarrisIntramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA.
Andrew T HattersleyGenetics of Diabetes, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Caroline HaywardMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, Scotland EH4 2XU, UK.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Jan-Håkan Jansson1] Department of Public Health &Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden [2] Research Unit, Skellefteå SE-931 87, Sweden.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Lenore J LaunerIntramural Research Program, National Institute on Aging, Bethesda, Maryland 21224, USA.
Daniel Levy1] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Christopher J O'Donnell1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Stephen O'RahillyUniversity of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 1TN, UK.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
Michael A ProvinceDivision of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908, USA.
Paul M Ridker1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Igor RudanCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, Scotland EH8 9YL, UK.
Matthias B Schulze1] Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal DE-14558, Germany [2] German Center for Diabetes Research (DZD), Neuherberg DE-85764, Germany.
Blair H SmithMedical Research Institute, University of Dundee, Dundee DD1 9SY, UK.
André G Uitterlinden1] Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne NE1 7RU, UK.
Hugh WatkinsDepartment of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tien Y Wong1] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore.
Eleftheria ZegginiThe Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
EPIC-InterAct Consortium
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio FI-70211, Finland.
Ingrid B BoreckiDivision of Statistical Genomics and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Daniel I Chasman1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA [2] Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Bruce M Psaty1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA [2] Department of Medicine, University of Washington, Seattle, Washington 98195, USA [3] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [4] Department of Health Services, University of Washington, Seattle, Washington 98195, USA [5] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98195, USA.
E Shyong Tai1] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Cornelia M van Duijn1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CE, The Netherlands [2] Center for Medical Systems Biology, Leiden 2300, The Netherlands.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Dawn M WaterworthGenetics, PCPS, GlaxoSmithKline, Philadelphia, Pennsylvania 19104, USA.
Eric Boerwinkle1] Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77225, USA [2] Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
W H Linda Kao1] Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205, USA [2] Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21205, USA [3] Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Jose C Florez1] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA [4] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Ruth J F Loos1] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [3] The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 38677, USA.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
David S Siscovick1] New York Academy of Medicine, New York, New York 10029, USA [2] Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98195, USA.
Josée Dupuis1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts 01702, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
James B Meigs1] Massachusetts General Hospital, General Medicine Division, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Mark O Goodarzi1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

Funding

The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI FLEISCHER, NORMAN S. · 1986 to 2014
$29.8M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
British Heart Foundation SP/04/002Chief Scientist Office CZD/16/6Chief Scientist Office CZD/16/6/4Department of Health RP-PG-0407-10371Intramural NIH HHS Z01 AG000949Intramural NIH HHS Z01 AG007390Medical Research Council G0600717Medical Research Council G0700931Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1-TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001422NCI NIH HHS CA047988NCI NIH HHS DP2 CA196375NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA182913NCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR000052NCRR NIH HHS RR-024156NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NEI NIH HHS EY017337NEI NIH HHS EY14684NEI NIH HHS R01 EY014684NEI NIH HHS U10 EY017337NHGRI NIH HHS 4R00HG006698-03NHGRI NIH HHS HG007112NHGRI NIH HHS R00 HG006698NHGRI NIH HHS R01 HG007112NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01-HG004729NHGRI NIH HHS U54 HG003273NHLBI NIH HHS 5RC2HL102419NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HL047887NHLBI NIH HHS HL047889NHLBI NIH HHS HL047890NHLBI NIH HHS HL060919NHLBI NIH HHS HL060944NHLBI NIH HHS HL061019NHLBI NIH HHS HL068986NHLBI NIH HHS HL071025-01A1NHLBI NIH HHS HL080295NHLBI NIH HHS HL080467NHLBI NIH HHS HL087652NHLBI NIH HHS HL087698NHLBI NIH HHS HL103612NHLBI NIH HHS HL105756NHLBI NIH HHS HL112064NHLBI NIH HHS HL120393NHLBI NIH HHS HL47902NHLBI NIH HHS HL58625-01A1NHLBI NIH HHS HL59684NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL060919NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01HL071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01HL071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01HL071259NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01-HL084099NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01-HL-087700NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01-HL-088215NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01-HL093029NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL107816NHLBI NIH HHS R01HL107816NHLBI NIH HHS R01 HL112064NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL072757NHLBI NIH HHS U01 HL047892NHLBI NIH HHS U01 HL047902NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01HL72518NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG023629NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS Z01 AG000949-02NIA NIH HHS Z01 AG007390-07NIDDK NIH HHS DK062370NIDDK NIH HHS DK063491NIDDK NIH HHS DK072193NIDDK NIH HHS DK081350NIDDK NIH HHS DK093757NIDDK NIH HHS K23 DK065978NIDDK NIH HHS K23 DK65978NIDDK NIH HHS K24 DK080140NIDDK NIH HHS K99 DK081350NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30DK063491NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R00 DK081350NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01-DK-075681NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK079888NIDDK NIH HHS R01DK079888NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01- DK-8925601NIDDK NIH HHS R56 DK062370NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK078616NINR NIH HHS NR0224103Wellcome Trust 075491/Z/04Wellcome Trust 084723/Z/08/ZWellcome Trust 095515Wellcome Trust 098051Wellcome Trust 100574Wellcome Trust WT091310Wellcome Trust WT098051
6 · The paper itself

Abstract

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01 mmol l(-1), P=3.4 × 10(-12)), T2D risk (OR[95%CI]=0.86[0.76-0.96], P=0.010), early insulin secretion (β=-0.07±0.035 pmolinsulin mmolglucose(-1), P=0.048), but higher 2-h glucose (β=0.16±0.05 mmol l(-1), P=4.3 × 10(-4)). We identify a gene-based association with FG at G6PC2 (pSKAT=6.8 × 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF=20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (β=0.02±0.004 mmol l(-1), P=1.3 × 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.

Indexed as

Genetic Predisposition to DiseaseGenetic VariationMutation RateOligonucleotide Array Sequence AnalysisBlack PeopleBlood GlucoseDiabetes Mellitus, Type 2ExomeFastingGenetic Association StudiesGenetic LociGlucagon-Like Peptide-1 ReceptorGlucose-6-PhosphataseHumansInsulinPolymorphism, Single NucleotideBlood GlucoseG6PC2 protein, humanGLP1R protein, humanGlucagon-Like Peptide-1 ReceptorGlucose-6-PhosphataseInsulin

Identifiers

PMID25631608
PMCPMC4311266

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