ArticleGenome biology2015
Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 65 citations in OpenAlex.
- Chromosome-level genome assembly of the sand martin (Riparia riparia).Scientific data · 2026Article
- Invariant HVC size in female canaries singing under testosterone: Unlocking function through neural differentiation, not growth.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- From silence to song: Testosterone triggers extensive transcriptional changes in the female canary HVC.Journal of neuroendocrinology · 2025Article
- Whole genome sequencing and assembly of the house sparrow,GigaByte (Hong Kong, China) · 2025Article
- Extensive GJD2 Expression in the Song Motor Pathway Reveals the Extent of Electrical Synapses in the Songbird Brain.Biology · 2021Article
- Chromosome-Level Genome Assembly of the Common Chaffinch (Aves: Fringilla coelebs): A Valuable Resource for Evolutionary Biology.Genome biology and evolution · 2021Article
- Neuroendocrine patterns underlying seasonal song and year-round territoriality in male black redstarts.Frontiers in zoology · 2021Article
- Article
- An Unbiased Molecular Approach Using 3'-UTRs Resolves the Avian Family-Level Tree of Life.Molecular biology and evolution · 2021Article
- The Gene Expression Profile of the Song Control Nucleus HVC Shows Sex Specificity, Hormone Responsiveness, and Species Specificity Among Songbirds.Frontiers in neuroscience · 2021Article
- Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain.Journal of molecular neuroscience : MN · 2020Article
- Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.Current biology : CB · 2019Article
- Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry.eLife · 2019Article
- Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation.Genes · 2019Article
- Gene expression vs. sequence divergence: comparative transcriptome sequencing among naturalFrontiers in zoology · 2019Article
- Feather Evolution from Precocial to Altricial Birds.Zoological studies · 2019Article
- Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes.Genome biology · 2018Article
- Review
- Draft genome assembly of the Bengalese finch, Lonchura striata domestica, a model for motor skill variability and learning.GigaScience · 2018Article
- Multidirectional chromosome painting inComparative cytogenetics · 2018Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhile the song of all songbirds is controlled by the same neural circuit, the hormone dependence of singing behavior varies greatly between species. For this reason, songbirds are ideal organisms to study ultimate and proximate mechanisms of hormone-dependent behavior and neuronal plasticity.
resultsWe present the high quality assembly and annotation of a female 1.2-Gbp canary genome. Whole genome alignments between the canary and 13 genomes throughout the bird taxa show a much-conserved synteny, whereas at the single-base resolution there are considerable species differences. These differences impact small sequence motifs like transcription factor binding sites such as estrogen response elements and androgen response elements. To relate these species-specific response elements to the hormone-sensitivity of the canary singing behavior, we identify seasonal testosterone-sensitive transcriptomes of major song-related brain regions, HVC and RA, and find the seasonal gene networks related to neuronal differentiation only in the HVC. Testosterone-sensitive up-regulated gene networks of HVC of singing males concerned neuronal differentiation. Among the testosterone-regulated genes of canary HVC, 20% lack estrogen response elements and 4 to 8% lack androgen response elements in orthologous promoters in the zebra finch.
conclusionsThe canary genome sequence and complementary expression analysis reveal intra-regional evolutionary changes in a multi-regional neural circuit controlling seasonal singing behavior and identify gene evolution related to the hormone-sensitivity of this seasonal singing behavior. Such genes that are testosterone- and estrogen-sensitive specifically in the canary and that are involved in rewiring of neurons might be crucial for seasonal re-differentiation of HVC underlying seasonal song patterning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.