ArticleScientific reports2015
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Tryptophan Metabolites in the Progression of Liver Diseases.Biomolecules · 2024Article
- Article
- Irisin Attenuates Apoptosis Following Ischemia-Reperfusion Injury Through Improved Mitochondria Dynamics and ROS Suppression Mediated Through the PI3K/Akt/mTOR Axis.Molecular neurobiology · 2023Article
- Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.Hepatology (Baltimore, Md.) · 2020Article
- Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress.Redox biology · 2019Article
- Noninvasive Imaging of Drug-Induced Liver Injury withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Platelets as Modulators of Liver Diseases.Seminars in thrombosis and hemostasis · 2018Review
- Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Optical control of paineLife · 2017Article
- Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation.PloS one · 2017Article
- 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice.Mediators of inflammation · 2017Article
- Platelets: No longer bystanders in liver disease.Hepatology (Baltimore, Md.) · 2016Review
- Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update.Journal of clinical and translational hepatology · 2016Review
- Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin.Stem cells international · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also involved in the hepatic physiological and pathological process. This study seeks to investigate the mechanisms involved in APAP-induced hepatotoxicity, as well as the role of 5-HT in the liver's response to APAP toxicity. We induced APAP hepatotoxicity in mice either sufficient of serotonin (wild-type mice and TPH1-/- plus 5- Hydroxytryptophan (5-HTP)) or lacking peripheral serotonin (Tph1-/- and wild-type mice plus p-chlorophenylalanine (PCPA)). Mice with sufficient 5-HT exposed to acetaminophen have a significantly lower mortality rate and a better outcome compared with mice deficient of 5-HT. This difference is at least partially attributable to a decreased level of inflammation, oxidative stress and endoplasmic reticulum (ER) stress, Glutathione (GSH) depletion, peroxynitrite formation, hepatocyte apoptosis, elevated hepatocyte proliferation, activation of 5-HT2B receptor, less activated c-Jun NH₂-terminal kinase (JNK) and hypoxia-inducible factor (HIF)-1α in the mice sufficient of 5-HT versus mice deficient of 5-HT. We thus propose a physiological function of serotonin that serotonin could ameliorate APAP-induced liver injury mainly through inhibiting hepatocyte apoptosis ER stress and promoting liver regeneration.
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