ArticleEuropean journal of medical research2015
Proteomic analysis of exosomes derived from human lymphoma cells.
Article in European journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic review on the role of MSC-derived exosomal miRNAs in the treatment of heart failure.Molecular biology reports · 2022Pooled it
- Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell-Activating Properties in B Cell Lymphoma.Journal of extracellular vesicles · 2026Article
- The multifaceted roles of extracellular vesicles for therapeutic intervention with non-Hodgkin lymphoma.Extracellular vesicles and circulating nucleic acids · 2024Article
- Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine.Materials (Basel, Switzerland) · 2022Review
- Proteome changes of plasma-derived extracellular vesicles in patients with myelodysplastic syndrome.PloS one · 2022Article
- Review
- Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma.Frontiers in oncology · 2021Review
- Experimental and Biological Insights from Proteomic Analyses of Extracellular Vesicle Cargos in Normalcy and Disease.Advanced biosystems · 2020Review
- Mass spectrometry-based proteome profiling of extracellular vesicles and their roles in cancer biology.Experimental & molecular medicine · 2019Review
- Extracellular Vesicles: New Players in Lymphomas.International journal of molecular sciences · 2018Review
- Article
- Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy.International journal of molecular sciences · 2017Review
- Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma.Oncotarget · 2016Review
- Transcriptomics Identify CD9 as a Marker of Murine IL-10-Competent Regulatory B Cells.Cell reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExosomes secreted by tumor cells contain specific antigens that may have immunotherapeutic purposes. The aim of this study was to characterize the proteomic content of lymphoma cell-derived exosomes (LCEXs).
methodsIn this study, exosomes derived from Raji cells (EXO(Raji)) were purified and proteins of EXO(Raji) were separated by one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis. Protein bands were identified by mass spectrometry. The protein components of EXO(Raji) were analyzed using shotgun technology, and the function proteins of EXO(Raji) were defined and described using the Gene Ontology (GO) database and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.
resultsA total of 197 proteins were identified in EXO(Raji); 139 proteins were also identified in Raji cells, showing an overlap of 70.56% of the total proteins in EXO(Raji). Interestingly, the remaining 58 proteins were unique to EXO(Raji). The GO database and KEGG were used to define and describe the function of proteins. The data showed that some important proteins involved in antigen procession and presentation as well as cell migration and adhesion were also identified in EXO(Raji), such as MHC-I and II, HSC70, HSP90, and ICMA-1.
conclusionsLCEXs express a discrete set of proteins involved in antigen presentation and cell migration and adhesion, suggesting that LCEXs play an important role in the regulation of immunity and interaction between lymphoma cells and their microenvironment. LCEXs harbor most of the proteins of lymphoma cells and could be one of the sources of lymphoma-associated antigens for immunotherapeutic purposes.
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