ArticleBritish journal of anaesthesia2015
Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome.
Article in British journal of anaesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Bedside monitoring of lung volume available for gas exchange.Intensive care medicine experimental · 2021Article
- Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury.Critical care medicine · 2020Article
- Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury.Intensive care medicine experimental · 2020Article
- Investigating Disturbances of Oxygen Homeostasis: From Cellular Mechanisms to the Clinical Practice.Frontiers in physiology · 2020Review
- Tidal changes in PaOBritish journal of anaesthesia · 2019Article
- Article
- Intermittent Hypoxia Severity in Animal Models of Sleep Apnea.Frontiers in physiology · 2018Article
- Gas Partial Pressure in Cultured Cells: Patho-Physiological Importance and Methodological Approaches.Frontiers in physiology · 2018Review
- Respiratory oscillations in alveolar oxygen tension measured in arterial blood.Scientific reports · 2017Article
- Cyclic PaOBMC anesthesiology · 2017Article
- Intravascular oxygen sensors with novel applications for bedside respiratory monitoring.Anaesthesia · 2017Review
- Experimental investigation of the effect of polymer matrices on polymer fibre optic oxygen sensors and their time response characteristics using a vacuum testing chamber and a liquid flow apparatus.Sensors and actuators. B, Chemical · 2016Article
- Conclusions From Inverse Ratio Ventilation Studied at a Respiratory Rate of 6 Breaths/Minute.Critical care medicine · 2015Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThere is considerable interest in oxygen partial pressure (Po2) monitoring in physiology, and in tracking Po2 changes dynamically when it varies rapidly. For example, arterial Po2 ([Formula: see text]) can vary within the respiratory cycle in cyclical atelectasis (CA), where [Formula: see text] is thought to increase and decrease during inspiration and expiration, respectively. A sensor that detects these [Formula: see text] oscillations could become a useful diagnostic tool of CA during acute respiratory distress syndrome (ARDS).
methodsWe developed a fibreoptic Po2 sensor (<200 µm diameter), suitable for human use, that has a fast response time, and can measure Po2 continuously in blood. By altering the inspired fraction of oxygen ([Formula: see text]) from 21 to 100% in four healthy animal models, we determined the linearity of the sensor's signal over a wide range of [Formula: see text] values in vivo. We also hypothesized that the sensor could measure rapid intra-breath [Formula: see text] oscillations in a large animal model of ARDS.
resultsIn the healthy animal models, [Formula: see text] responses to changes in [Formula: see text] were in agreement with conventional intermittent blood-gas analysis (n=39) for a wide range of [Formula: see text] values, from 10 to 73 kPa. In the animal lavage model of CA, the sensor detected [Formula: see text] oscillations, also at clinically relevant [Formula: see text] levels close to 9 kPa.
conclusionsWe conclude that these fibreoptic [Formula: see text] sensors have the potential to become a diagnostic tool for CA in ARDS.
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