ArticleCritical care (London, England)2015
Intraoperative renal near-infrared spectroscopy indicates developing acute kidney injury in infants undergoing cardiac surgery with cardiopulmonary bypass: a case-control study.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of NIRS to Detect Acute Kidney Injury in Preterm Infants
Renal Oxygen Saturation Measured by Near-Infrared Spectroscopy for the Early Recognition of Acute Kidney Injury in Asphyxiated Neonates Undergoing Therapeutic Hypothermia: A Prospective Observational Cohort Study
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Perioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Pooled it
- A meta-analysis of the incidence rate of postoperative acute kidney injury in patients with congenital heart disease.BMC nephrology · 2020Pooled it
- Intraoperative hemodynamics and risk of cardiac surgery-associated acute kidney injury: An observation study and a feasibility clinical trial.Clinical and experimental pharmacology & physiology · 2023Trial
- Putting the pieces together: solving the puzzle of early acute kidney injury post pediatric cardiac surgery.Pediatric research · 2026Article
- Intraoperative renal oxygen saturation trajectories are associated with early postoperative acute kidney injury after liver transplantation.Scientific reports · 2026Article
- Intraoperative renal and cerebral tissue oxygen saturation measurements to predict postoperative acute kidney injury in pediatric cardiac surgery: a prospective observational study.Journal of clinical monitoring and computing · 2026Observational
- Renal regional oxygenation during pediatric cardiac surgery predicts acute kidney injury: a prospective cohort study with model comparisons.Pediatric research · 2026Article
- Acute Effects of Aminophylline Effects on Hemodynamic Parameters and Fluid Balance in Pediatric Cardiac Intensive Care Patients: Machine Learning Insights Using High Fidelity Data.Pediatric cardiology · 2025Article
- Association of renal regional tissue oxygen saturation and post-procedural acute kidney injury following transcatheter aortic valve implantation.Journal of clinical monitoring and computing · 2025Observational
- Intraoperative Renal Near-Infrared Spectroscopy Monitoring as a Predictor of Renal Outcomes in Cardiac Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- Real-time organ perfusion monitoring of human kidney transplants usingRoyal Society open science · 2025Article
- A Prospective Observational Study on Role of Intraoperative Renal & Muscle Oxygen Saturation on Post-operative Serum Creatinine Level in Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass.Journal of the Saudi Heart Association · 2025Article
- Fluid Overload and AKI After the Norwood Operation: The Correlation and Characterization of Routine Clinical Markers.Pediatric cardiology · 2024Article
- Review
- Association between muscular tissue desaturation and acute kidney injury in older patients undergoing major abdominal surgery: a prospective cohort study.Journal of anesthesia · 2024Article
- Decreased Intraoperative Renal Tissue Oxygenation after Cardiopulmonary Bypass Predicts Cardiac Surgery-Associated Acute Kidney Injury in Neonates.Children (Basel, Switzerland) · 2024Article
- Oxygen in the neonatal ICU: a complicated history and where are we now?Frontiers in pediatrics · 2024Review
- Association of intraoperative cerebral and somatic tissue oxygen saturation with postoperative acute kidney injury in adult patients undergoing multiple valve surgery.BMC anesthesiology · 2023Article
- Renal oximetry for early acute kidney injury detection in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2023Observational
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute kidney injury (AKI) is a frequent complication after cardiac surgery with cardiopulmonary bypass in infants. Renal near-infrared spectroscopy (NIRS) is used to evaluate regional oximetry in a non-invasive continuous real-time fashion, and reflects tissue perfusion. The aim of this study was to evaluate the relationship between renal oximetry and development of AKI in the operative and post-operative setting in infants undergoing cardiopulmonary bypass surgery.
methodsIn this prospective study, we enrolled 59 infants undergoing cardiopulmonary bypass surgery for congenital heart disease for univentricular (n = 26) or biventricular (n = 33) repair. Renal NIRS was continuously measured intraoperatively and for at least 24 hours postoperatively and analysed for the intraoperative and first 12 hours, first 24 hours and first 48 hours postoperatively. The renal oximetry values were correlated with the paediatric risk, injury, failure, loss, end (pRIFLE) classification for AKI, renal biomarkers and the postoperative course.
resultsTwenty-eight (48%) infants developed AKI based on pRIFLE classification. Already during intraoperative renal oximetry and further in the first 12 hours, 24 hours and 48 hours postoperatively, significantly lower renal oximetry values in AKI patients compared with patients with normal renal function were recorded (P < 0.05). Of the 28 patients who developed AKI, 3 (11%) needed renal replacement therapy and 2 (7%) died. In the non-AKI group, no deaths occurred. Infants with decreased renal oximetry values developed significantly higher lactate levels 24 hours after surgery. Cystatin C was a late parameter of AKI, and neutrophil gelatinase-associated lipocalin values were not correlated with AKI occurrence.
conclusionOur results suggest that prolonged low renal oximetry values during cardiac surgery correlate with the development of AKI and may be superior to conventional biochemical markers. Renal NIRS might be a promising non-invasive tool of multimodal monitoring of kidney function and developing AKI in infants undergoing cardiac surgery with cardiopulmonary bypass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.