Evidence map›Paper›PMID 25631310›Full record

SynthesisBMJ open2015

Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis.

Yoon Frederiksen, Ingeborg Farver-Vestergaard, Ninna Grønhøj Skovgård, Hans Jakob Ingerslev, Robert Zachariae

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04703725 (The Effect of the Counseling on Women in In Vitro Fertilization), which is not on this map. Cited by 126 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 13 pooled it
30.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04703725 nacompletednot on this mapstarted 2020, after this paper: background citation

The Effect of the Counseling on Women in In Vitro Fertilization (IVF) Process on Emotional Capacity and Well-Being

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2020 to 2021Enrolled85ConditionsInfertility, Psychological Distress, Infertility, Female, Depression, AnxietyArmsPsychosocial Care
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 13 syntheses or guidelines pooled it, 374 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yoon FrederiksenUnit for Psychooncology and Health Psychology, Department of Psychology, Aarhus University, Aarhus, Denmark.
Ingeborg Farver-VestergaardUnit for Psychooncology and Health Psychology, Department of Psychology, Aarhus University, Aarhus, Denmark.
Ninna Grønhøj SkovgårdUnit for Psychooncology and Health Psychology, Department of Psychology, Aarhus University, Aarhus, Denmark.
Hans Jakob IngerslevSkejby Fertility Clinic, Aarhus University Hospital, Aarhus, Denmark.
Robert ZachariaeUnit for Psychooncology and Health Psychology, Department of Psychology, Aarhus University, Aarhus, Denmark Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Aarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the evidence on the efficacy of psychosocial interventions for improving pregnancy rates and reducing distress for couples in treatment with assisted reproductive technology (ART).

designSystematic review and meta-analysis. DATA SOURCES: PsycINFO, PubMed, EMBASE, CINAHL, Web of Science and The Cochrane Library between 1978 and April 2014. STUDY SELECTION: Studies were considered eligible if they evaluated the effect of any psychosocial intervention on clinical pregnancy and/or distress in infertile participants, used a quantitative approach and were published in English. DATA EXTRACTION: Study characteristics and results were extracted and the methodological quality was assessed. Effect sizes (ES; Hedges g) were pooled using a random effects model. Heterogeneity was assessed using the Q statistic and I(2), and publication bias was evaluated using Egger's method. Possible moderators and mediators were explored with meta-analyses of variances (ANOVAs) and meta-regression.

resultsWe identified 39 eligible studies (total N=2746 men and women) assessing the effects of psychological treatment on pregnancy rates and/or adverse psychological outcomes, including depressive symptoms, anxiety, infertility stress and marital function. Statistically significant and robust overall effects of psychosocial intervention were found for both clinical pregnancy (risk ratio=2.01; CI 1.48 to 2.73; p<0.001) and combined psychological outcomes (Hedges g=0.59; CI 0.38 to 0.80; p=0.001). The pooled ES for psychological outcomes were generally larger for women (g: 0.51 to 0.73) than men (0.13 to 0.34), but the difference only reached statistical significance for depressive symptoms (p=0.004). Meta-regression indicated that larger reductions in anxiety were associated with greater improvement in pregnancy rates (Slope 0.19; p=0.004). No clear-cut differences were found between effects of cognitive-behavioural therapy (CBT; g=0.84), mind-body interventions (0.61) and other intervention types (0.50).

conclusionsThe present meta-analysis suggests that psychosocial interventions for couples in treatment for infertility, in particular CBT, could be efficacious, both in reducing psychological distress and in improving clinical pregnancy rates.

Indexed as

FemaleHumansInfertilityMaleMental DisordersPregnancyPregnancy OutcomePregnancy RatePsychotherapyReproductive Techniques, AssistedTreatment OutcomedistressInfertilitypregnancyPsychosocial intervention

Identifiers

PMID25631310
PMCPMC4316425
OpenAlexW2103859384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.