ReviewMicrobiology and molecular biology reviews : MMBR2015
The Clostridium sporulation programs: diversity and preservation of endospore differentiation.
Review in Microbiology and molecular biology reviews : MMBR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed, 177 citations in OpenAlex.
- From observable fermentation data to hidden cell states: A modeling study of a mixotrophic Clostridium coculture under perfusion mode.PLoS computational biology · 2026Article
- Distinctive spore architecture and developmental biology ofJournal of bacteriology · 2026Article
- Cyclic di-adenosine monophosphate as a potential regulator of sporulation and solventogenesis in Clostridium beijerinckii: a hypothesis.World journal of microbiology & biotechnology · 2026Review
- DUF4004 protein BacR (YhbD) ofFrontiers in microbiology · 2026Article
- Review
- Distinct modes of cell division drivemBio · 2025Article
- Agglutination of Escherichia coli, Clostridium perfringens, and Salmonella enterica through competitive exclusion using potassium chloride with gum arabic.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Enhancement of the start-up and performance of an upflow anaerobic sludge blanket (UASB) reactor using electrochemically-enriched biofilm.Enzyme and microbial technology · 2025Article
- Adapting to UV: Integrative Genomic and Structural Analysis in Bacteria from Chilean Extreme Environments.International journal of molecular sciences · 2025Article
- Lignocellulose-derived inhibitors can extend residence of Clostridium beijerinckii in active solventogenic state.Bioresources and bioprocessing · 2025Article
- Article
- Overexpressing theToxins · 2024Article
- Review
- SpoIVA is an essential morphogenetic protein for the formation of heat- and lysozyme-resistant spores inFrontiers in microbiology · 2024Article
- Clostridioides difficile Biofilm.Advances in experimental medicine and biology · 2024Article
- A Novel Prophage-like Insertion Element withinViruses · 2023Article
- A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile.PLoS pathogens · 2023Article
- Article
- The Lanthipeptide Synthetase-like Protein CA_C0082 Is an Effector of Agr Quorum Sensing inMicroorganisms · 2023Article
- Regulatory transcription factors ofCritical reviews in microbiology · 2023Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryBacillus and Clostridium organisms initiate the sporulation process when unfavorable conditions are detected. The sporulation process is a carefully orchestrated cascade of events at both the transcriptional and posttranslational levels involving a multitude of sigma factors, transcription factors, proteases, and phosphatases. Like Bacillus genomes, sequenced Clostridium genomes contain genes for all major sporulation-specific transcription and sigma factors (spo0A, sigH, sigF, sigE, sigG, and sigK) that orchestrate the sporulation program. However, recent studies have shown that there are substantial differences in the sporulation programs between the two genera as well as among different Clostridium species. First, in the absence of a Bacillus-like phosphorelay system, activation of Spo0A in Clostridium organisms is carried out by a number of orphan histidine kinases. Second, downstream of Spo0A, the transcriptional and posttranslational regulation of the canonical set of four sporulation-specific sigma factors (σ(F), σ(E), σ(G), and σ(K)) display different patterns, not only compared to Bacillus but also among Clostridium organisms. Finally, recent studies demonstrated that σ(K), the last sigma factor to be activated according to the Bacillus subtilis model, is involved in the very early stages of sporulation in Clostridium acetobutylicum, C. perfringens, and C. botulinum as well as in the very late stages of spore maturation in C. acetobutylicum. Despite profound differences in initiation, propagation, and orchestration of expression of spore morphogenetic components, these findings demonstrate not only the robustness of the endospore sporulation program but also the plasticity of the program to generate different complex phenotypes, some apparently regulated at the epigenetic level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.