ArticleJournal of materials science. Materials in medicine2015
Effect of sterilization and crosslinking on gelatin films.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Gelatin-St. John's Wort Oil Matrices: Material Properties for Potential Biomedical Applications.Polymers · 2026Article
- Biopolymer-Based Electrospun Nanofibers for Wound Healing, Regeneration, and Therapeutics.Materials (Basel, Switzerland) · 2026Review
- Substrate-Dependent Variability in Viability and Angiogenic Marker Expression Among Three Endothelial Cell Subtypes: Insights for Artificial Tissue Vascularization.Macromolecular bioscience · 2025Article
- The Role of WOGels (Basel, Switzerland) · 2024Article
- Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Effects of Gamma Irradiation and Supercritical Carbon Dioxide Sterilization on Methacrylated Gelatin/Hyaluronan Hydrogels.Journal of functional biomaterials · 2023Article
- A New Method to Determine Antioxidant Activities of Biofilms Using a pH Indicator (Resazurin) Model System.Molecules (Basel, Switzerland) · 2023Article
- Characterization of Dual-Layer Hybrid Biomatrix for Future Use in Cutaneous Wound Healing.Materials (Basel, Switzerland) · 2023Article
- Gallic Acid Crosslinked Gelatin and Casein Based Composite Films for Food Packaging Applications.Polymers · 2022Article
- Engineering Hydrogels for the Development of Three-Dimensional In Vitro Models.International journal of molecular sciences · 2022Review
- Curcumin-Functionalized Gelatin Films: Antioxidant Materials with Modulated Physico-Chemical Properties.Polymers · 2021Article
- Microwave-assisted Preparation of Cross-linked Gelatin-Paracetamol Matrices: Optimization Using the D-optimal DesignTurkish journal of pharmaceutical sciences · 2021Article
- Effect of sterilization treatment on mechanical properties, biodegradation, bioactivity and printability of GelMA hydrogels.Biomedical materials (Bristol, England) · 2020Article
- Mechanically Reinforced Gelatin Hydrogels by Introducing Slidable Supramolecular Cross-Linkers.Polymers · 2019Article
- Multiplatform Protein Detection and Quantification Using Glutaraldehyde-Induced Fluorescence for 3D Systems.Journal of fluorescence · 2019Article
- Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sterilization through γ-irradiation has been reported to affect collagen mechanical properties, but its possible effects on gelatin based materials have not been investigated up to now. Herein we report the results of a mechanical, chemical and thermal study performed on gelatin films before and after γ-irradiation. The investigation was performed on uncrosslinked films as well as on crosslinked films. To this aim, two common crosslinking agents, glutaraldehyde and genipin, at different concentration (0.15, 0.30 and 0.67%) were used. The results indicate that sterilization significantly affects the mechanical properties of uncrosslinked films, whereas it displays a modest effect on gelatin swelling, release in solution, thermal stability and molecular structure. Both glutaraldehyde and genipin enhance the mechanical properties and stability in solution of the gelatin films. In particular, the values of Young modulus increase as a function of crosslinker concentration up to about 10 and 18 MPa for genipin and glutaraldehyde treated samples respectively. The results of in vitro study demonstrate that the films crosslinked with genipin do not display any cytotoxic reaction, whereas glutaraldehyde crosslinking provokes an acute and dose dependent cytotoxic effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.