Evidence map›Paper›PMID 25631218›Full record

ReviewJournal of human hypertension2015

The renin-angiotensin-aldosterone system and calcium-regulatory hormones.

A Vaidya, J M Brown, J S Williams

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
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  8. Hypocalcemic Tetany Transiently "Cured" by Pregnancy: A Case Report.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
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  15. Review
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  19. Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

A Vaidya1] Center for Adrenal Disorders, Harvard Medical School, Boston, MA, USA [2] Division of Endocrinology, Diabetes, and Hypertension, Harvard Medical School, Boston, MA, USA [3] Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J M BrownBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J S Williams1] Division of Endocrinology, Diabetes, and Hypertension, Harvard Medical School, Boston, MA, USA [2] Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · US

Funding

Vitamin D and Hormonal Mechanisms of Cardiovascular Disease in ObesityK23HL111771 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2012 to 2016
$805k
NHLBI NIH HHS K23 HL11177NHLBI NIH HHS K23 HL111771NHLBI NIH HHS L30 HL104553
6 · The paper itself

Abstract

There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium-regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis, while the latter is most often associated with skeletal health. However, emerging evidence suggests an overlap in regulatory control. Hyperaldosteronism and hyperparathyroidism represent pathophysiologic conditions that may contribute to or perpetuate each other; aldosterone regulates parathyroid hormone and associates with adverse skeletal complications, and parathyroid hormone regulates aldosterone and associates with adverse cardiovascular complications. As dysregulation in both systems is linked to poor cardiovascular and skeletal health, it is increasingly important to fully characterize how they interact to more precisely understand their impact on human health and potential therapies to modulate these interactions. This review describes the known clinical interactions between these two systems including observational and interventional studies. Specifically, we review studies describing the inhibition of renin activity by calcium and vitamin D, and a potentially bidirectional and stimulatory relationship between aldosterone and parathyroid hormone. Deciphering these relationships might clarify variability in outcomes research, inform the design of future intervention studies and provide insight into the results of prior and ongoing intervention studies. However, before these opportunities can be addressed, more effort must be placed on shifting observational data to the proof of concept phase. This will require reallocation of resources to conduct interventional studies and secure the necessary talent.

Indexed as

Renin-Angiotensin SystemAldosteroneAnimalsBlood PressureCalciumCardiovascular DiseasesHumansParathyroid HormoneSignal TransductionVitamin DWater-Electrolyte BalanceAldosteroneCalciumParathyroid HormonePTH protein, humanVitamin D

Identifiers

PMID25631218
PMCPMC4769794
OpenAlexW2074187263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.