Evidence map›Paper›PMID 25631206›Full record

ReviewAnnals of biomedical engineering2015

Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval.

Benedikt L Proffen, Gabriel S Perrone, Gordon Roberts, Martha M Murray

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Biomaterials to Mimic and Heal Connective Tissues.Advanced materials (Deerfield Beach, Fla.) · 2019
    Review
  16. Article
  17. Article
  18. Polymeric 3D Printed Structures for Soft-Tissue Engineering.Journal of applied polymer science · 2018
    Article
  19. Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benedikt L ProffenSports Medicine Research Laboratory, Department of Orthopaedic Surgery, Boston Children's Hospital/Harvard Medical School, Enders Building, Room 270, 300 Longwood Avenue, Boston, MA, 02115, USA.
Gabriel S Perrone
Gordon Roberts
Martha M Murray
Boston Children's Hospital · US

Funding

Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
The Effect of Age on Functional ACL HealingR01AR054099 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI MURRAY, MARTHA M · 2006 to 2013
$4.8M
NIAMS NIH HHS 1R01-AR056834NIAMS NIH HHS 1R01-AR056834S1NIAMS NIH HHS 2R01-AR054099NIAMS NIH HHS R01 AR054099NIAMS NIH HHS R01 AR056834
6 · The paper itself

Abstract

Injuries to the anterior cruciate ligament (ACL) are currently treated with replacement of the torn ligament with a graft of tendon harvested from elsewhere in the knee. This procedure, called "ACL reconstruction," is excellent for restoring gross stability to the knee; however, there are relatively high graft failure rates in adolescent patients (Barber et al. in Arthroscopy 30(4):483-491, (2014); Engelman et al. in Am J Sports Med, (2014); Webster et al. in Am J Sports Med 42(3):641-647, (2014)), and the ACL reconstruction procedure does not prevent the premature osteoarthritis seen in patients after an ACL injury (Ajuied et al. in Am J Sports Med, (2013); Song et al. in J Sports Med 41(10):2340-2346, (2013); Tourville et al. Am J Sports Med 41(4):769-778, (2013)) .Thus, new solutions are needed for ACL injuries. Researchers have been investigating the use of scaffolds, growth factors and cells to supplement a suture repair of the ACL (bridge-enhanced repair; also called bio-enhanced repair in prior publications). In this paper, we will review the varied approaches which have been investigated for stimulating ACL healing and repair in preclinical models and how one of these technologies was able to move from promising preclinical results to FDA acceptance of an investigational device exemption application for a first-in-human study.

Indexed as

Anterior Cruciate Ligament ReconstructionDevice ApprovalTissue ScaffoldsAnimalsAnterior Cruciate Ligament InjuriesHumansMedical Device LegislationUnited States

Identifiers

PMID25631206
PMCPMC4799652
OpenAlexW2009733587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.