ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder.
Abstract readComparative Study
In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- The Association between Lead and Attention-Deficit/Hyperactivity Disorder: A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone.Chemical research in toxicology · 2026Article
- Maternal pesticide exposure disrupts local inhibitory circuits in the reward pathway.Environment international · 2026Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- The gut microbiome promotes detoxification responses to an environmental toxicant.bioRxiv : the preprint server for biology · 2025Article
- Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders.Journal of xenobiotics · 2025Review
- Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain.Physiological genomics · 2025Article
- Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons.Journal of hazardous materials · 2025Article
- Association between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study.Italian journal of pediatrics · 2025Article
- Folate prevents the autism-related phenotype caused by developmental pyrethroid exposure in prairie voles.bioRxiv : the preprint server for biology · 2024Article
- A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring.Environmental health : a global access science source · 2024Article
- Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood.Neurotoxicology · 2024Article
- Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood.bioRxiv : the preprint server for biology · 2024Article
- Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain.bioRxiv : the preprint server for biology · 2024Article
- Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study.Environmental health perspectives · 2023Article
- Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.Brain sciences · 2023Article
- Effects of prenatal pesticide exposure on the fetal brain and placenta transcriptomes in a rodent model.Toxicology · 2023Article
- Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice.PNAS nexus · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Jason R Richardson*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA jricha3@eohsi.rutgers.edu.
Michele M Taylor*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Stuart L Shalat*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Thomas S Guillot*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
W Michael Caudle*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Muhammad M Hossain*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Tiffany A Mathews*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Sara R Jones*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Deborah A Cory-Slechta*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Gary W Miller*Department of Environmental and Occupational Medicine and Environmental and Occupational Health Sciences Institute, Rutgers-Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA; Center for Neurodegenerative Disease, School of Medicine, and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA; Department of Chemistry, Wayne State University, Detroit, Michigan, USA; and Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Environmental and Occupational Health Sciences Institute · USInstitute for Neurodegenerative Disorders · USEmory University · USUniversity of Rochester Medical Center · USWake Forest University · USWayne State University · US
Funding
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4MTROPANE EVALUATION AND GENERAL SCIENTIFIC SERVICES COREP50DA006634 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PORRINO, LINDA J. · 1991 to 2019
$30.8MTRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4MMULTI-DISCIPLINARY TRAINING IN THE BIOLOGY OF ALCOHOLISMT32AA007565 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRIAN A MCCOOL · 1994 to 2026
$10.1MGraduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1MRole of Kappa Opioid Receptors in Maladaptive Catecholamine Responses to Stress and Alcohol ExposureU01AA014091 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Katherine Mercedes Holleran, SARA RAULERSON JONES · 2003 to 2026
$7.7MVESICULAR MONOAMINE TRANSPORTER:TOXICANT TARGETU54ES012068 · NIEHS · EMORY UNIVERSITY · PI DELONG, MAHLON R · 2002 to 2007
$7.5MMechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHDR01ES015991 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI RICHARDSON, JASON R · 2007 to 2011
$3.2MTranslational Studies on Early-life Stress and Vulnerability to Alcohol AddictionP01AA021099 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEINER, JEFFREY L. · 2012 to 2016
$2.8MTranslational Centerfor the Neurobehaviral Study of AlcoholP01AA017056 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEINER, JEFFREY L. · 2008 to 2012
$2.0MDopamine Transporter Changes Following Cocaine Self-AdministrationR01DA021325 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2007 to 2011
$1.4MValidation of a Robotic Surrogate for Measurement of Early Childhood Personal ExpR01ES020415 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI SHALAT, STUART LLOYD · 2011 to 2012
$895kNIAAA NIH HHS P01 AA017056NIAAA NIH HHS P01 AA021099NIAAA NIH HHS T32 AA007565NIAAA NIH HHS U01 AA014091NIDA NIH HHS P50 DA006634NIDA NIH HHS P50DA006634NIDA NIH HHS R01 DA021325NIDA NIH HHS R01DA021325NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022NIEHS NIH HHS R01ES012702NIEHS NIH HHS R01 ES015991NIEHS NIH HHS R01ES015991NIEHS NIH HHS R01ES015991-04S1NIEHS NIH HHS R01 ES020415NIEHS NIH HHS R01ES020415NIEHS NIH HHS R21 ES012315NIEHS NIH HHS R21ES012315NIEHS NIH HHS R21 ES013828NIEHS NIH HHS R21ES013828NIEHS NIH HHS T32 ES007148NIEHS NIH HHS T32ES007148NIEHS NIH HHS T32 ES012870NIEHS NIH HHS T32ES012870NIEHS NIH HHS U54 ES012068NIEHS NIH HHS U54ES012068
Abstract
Attention-deficit hyperactivity disorder (ADHD) is estimated to affect 8-12% of school-age children worldwide. ADHD is a complex disorder with significant genetic contributions. However, no single gene has been linked to a significant percentage of cases, suggesting that environmental factors may contribute to ADHD. Here, we used behavioral, molecular, and neurochemical techniques to characterize the effects of developmental exposure to the pyrethroid pesticide deltamethrin. We also used epidemiologic methods to determine whether there is an association between pyrethroid exposure and diagnosis of ADHD. Mice exposed to the pyrethroid pesticide deltamethrin during development exhibit several features reminiscent of ADHD, including elevated dopamine transporter (DAT) levels, hyperactivity, working memory and attention deficits, and impulsive-like behavior. Increased DAT and D1 dopamine receptor levels appear to be responsible for the behavioral deficits. Epidemiologic data reveal that children aged 6-15 with detectable levels of pyrethroid metabolites in their urine were more than twice as likely to be diagnosed with ADHD. Our epidemiologic finding, combined with the recapitulation of ADHD behavior in pesticide-treated mice, provides a mechanistic basis to suggest that developmental pyrethroid exposure is a risk factor for ADHD.
Indexed as
AdolescentAnimalsAttention Deficit Disorder with HyperactivityAvoidance LearningBlotting, WesternCase-Control StudiesChildChromatography, High Pressure LiquidCross-Sectional StudiesDopamine Plasma Membrane Transport ProteinsFemaleHumansInsecticidesLocomotionMaleMaze LearningdecamethrinDopamine Plasma Membrane Transport ProteinsInsecticidesNitrilesPyrethrinsReceptors, Dopamine D1ADHDdopamine receptordopamine transporterimpulsivitypyrethyroid
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