ReviewAutonomic neuroscience : basic & clinical2015
Muscle mechanoreflex overactivity in hypertension: a role for centrally-derived nitric oxide.
Review in Autonomic neuroscience : basic & clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Six weeks stretching of lower limbs lowers blood pressure in hypertensive individuals.European journal of applied physiology · 2026Article
- Obesity does not alter vascular function and handgrip exercise hemodynamics in middle-aged patients with hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Eight weeks of inorganic nitrate/nitrite supplementation improves aerobic exercise capacity and the gas exchange threshold in patients with type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Gene and protein expression of dorsal root ganglion sensory receptors in normotensive and hypertensive male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Exercise Pressor Reflex Contributes to the Cardiovascular Abnormalities Characterizing: Hypertensive Humans During Exercise.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Mineralocorticoids: the secret of muscle reflex dysfunction in hypertension?American journal of physiology. Heart and circulatory physiology · 2017Article
- Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men.The Journal of physiology · 2016Article
- Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2016Article
- Exercise, the Brain, and Hypertension.Current hypertension reports · 2015Review
- Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The cardiovascular response to exercise is abnormally large in hypertension. Over the past decade, it has become clear that the exercise pressor reflex (a peripheral feed-back mechanism originating in skeletal muscle) contributes significantly to the generation of this hyper-responsiveness. Further, it has been determined that overactivity of the mechanically (muscle mechanoreflex) and chemically (muscle metaboreflex) sensitive components of the exercise pressor reflex underpin its dysfunction. Given the recent attention in the literature, this review focuses upon the aberrant function of the muscle mechanoreflex in this disease. Evidence supporting a role for the mechanoreflex in the pathogenesis of the exaggerated cardiovascular response to physical activity is highlighted. The peripheral and central mechanisms that may be responsible for mechanoreflex overactivity in hypertension are likewise discussed. Particular attention is given to emerging evidence implicating a role for centrally-derived nitric oxide in this process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.