ArticlePharmaceutical research2015
In vitro, ex vivo and in silico mechanistic elucidation of the performance of an optimized porosity-controlled multi-elemental transbuccal system.
Article in Pharmaceutical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight usingBiomolecules · 2020Article
- In silico analytico-mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations.Bioengineering & translational medicine · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo elucidate the mechanisms of construction and performance of a porosity controlled, multi-elemental transbuccal system employing experimental and computational approaches.
methodsThe production of the formulation was guided through a Box-Benkhen design employing homogenization coupled with lyophilization. The physicochemical and physicomechanical properties of the experimental design formulations were quantified with relevant analytical techniques. The influence of changes in porosity measures on the magnitude of these physical properties were explored mathematically. Furthermore, experimental outputs from the Box-Behnken design formulations were fitted into set limits and optimized using the response surface method. The optimized porosity-controlled formulation was subjected to mechanistic experimental and computational elucidations.
resultsIn general, the changes in magnitudes of studied porosity quantities had significant impact on formulation physicochemical and physicomechanical properties. The generation of an optimized formulation validated the stability and accuracy of the Box-Behnken experimental design. Experimental investigations revealed that the construction of this formulation is as a result of non-destructive physical interactions amongst its make-up compounds while its mechanism of performance is anchored mainly upon a gradual collapse of its ordered porous structure. Furthermore, the molecule mechanics simulations quantitatively predicted the molecular interactions inherent to multicomponent matrix formation and the mucoadhesion mechanism.
conclusionsThe fabrication and performance mechanisms of the porosity-controlled transbuccal system was successfully explored.
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Registered trials
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