ArticlePsychophysiology2015
Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.
Article in Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Do divorce and widowhood increase mortality risk? A 35-year longitudinal cohort study in a Norwegian population: the HUNT study.BMJ public health · 2026Article
- From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior.Current psychiatry reports · 2024Review
- Discrete Survival Time Constructions for Studying Marital Formation and Dissolution in Rural South Africa.Frontiers in psychology · 2020Article
- DNA Methylation Across the Serotonin Transporter Gene Following Marital Separation: A Pilot Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- Heart Rate Variability Moderates the Association Between Separation-Related Psychological Distress and Blood Pressure Reactivity Over Time.Psychological science · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Marital separation is linked to negative mental and physical health; however, the strength of this link may vary across people. This study examined changes in respiratory sinus arrhythmia (RSA), used to assess cardiac vagal control, in recently separated adults (N = 79; M time since separation = 3.5 months). When reflecting on the separation, self-reported psychological distress following the separation interacted with a polymorphism in the serotonin transporter gene (5-HTTLPR) and a relevant single nucleotide polymorphism (SNP), rs25531, to predict RSA. Among people reporting emotional difficulties after the separation, those who were homozygous for the short allele had lower RSA levels while reflecting on their relationship than other genotypes. The findings, although limited by the relatively small sample size, are discussed in terms of how higher-sensitivity genotypes may interact with psychological responses to stress to alter physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.