SynthesisScientific reports2015
Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Cytochrome P450 1A1 gene polymorphisms and digestive tract cancer susceptibility: a meta-analysis.Journal of cellular and molecular medicine · 2016Pooled it
- A genetic polymorphism affects the risk and prognosis of renal cell carcinoma: association with follistatin-like protein 1 expression.Scientific reports · 2016Trial
- Advanced stratification analyses in molecular association meta-analysis: methodology and application.BMC medical research methodology · 2020Article
- New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases.Acta pharmaceutica Sinica. B · 2020Review
- Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Contribution of IDO to human respiratory syncytial virus infection.Journal of leukocyte biology · 2019Review
- Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and AtherosclerosisAsian Pacific journal of cancer prevention : APJCP · 2018Review
- Overexpression of aryl hydrocarbon receptor (AHR) signalling pathway in human meningioma.Journal of neuro-oncology · 2018Article
- Article
- Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma.Oncology letters · 2018Article
- Association of CytochromeFrontiers in public health · 2018Article
- Biochemical characterization of variants of canine CYP1A1 using heterologous expression.The Journal of veterinary medical science · 2017Article
- CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk.Mutation research. Genetic toxicology and environmental mutagenesis · 2017Article
- The associations between five polymorphisms of vascular endothelial growth factor and renal cell carcinoma risk: an updated meta-analysis.OncoTargets and therapy · 2017Article
- DNA repair system and renal cell carcinoma prognosis: under the influence of NBS1.Medical oncology (Northwood, London, England) · 2015Article
Corrections and comments
- Retraction · 2025-01-22Author Unresponsive · Concerns/Issues about Article · Error in Text · Euphemisms for Plagiarism · Investigation by Journal/Publisher · Plagiarism of Text · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450 1A1 (CYP1A1) usually metabolizes carcinogens to their inactive derivatives but occasionally converts the chemicals to more potent carcinogens. To date, many studies have evaluated the association between the CYP1A1 MspI and Ile462Val polymorphisms and renal cell carcinoma (RCC) risk, but the results have been conflicting. To more precisely evaluate the potential association, we carried out a meta-analysis of seven published case-control studies. The meta-analysis indicated that the MspI polymorphism was associated with an increased RCC risk (allele model: OR = 1.49, 95%CI 1.03-2.16; homozygous model: OR = 1.64, 95%CI 1.13-2.40; dominant model: OR = 1.72, 95%CI 1.07-2.76). No significant associations were found for the Ile462Val polymorphism for all genetic models. When stratified by smoking status, smokers carrying the variant Vt and Val allele were more susceptible to RCC (Vt allele: OR = 3.37, 95%CI = 2.24-5.06; Val allele: OR = 2.07, 95%CI = 1.34-3.19). These data indicate that the CYP1A1 MspI polymorphism significantly increased RCC risk, while the Ile462Val polymorphism was not associated with RCC. Among smokers, individuals with the CYP1A1 Vt allele and Val allele showed a significantly increased risk of RCC. More well-designed studies with larger samples are warranted to show the underlying mechanisms of CYP1A1 in the development of RCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.