Evidence map›Paper›PMID 25630528›Full record

ArticleClinical lymphoma, myeloma & leukemia2015

Characteristics of Sweet Syndrome in patients with acute myeloid leukemia.

Syed M Kazmi, Naveen Pemmaraju, Keyur P Patel, Philip R Cohen, Naval Daver, Kathy M Tran, Farhad Ravandi, Madeleine Duvic, Guillermo Garcia-Manero, Sherry Pierce and 4 more

Open access · greenAbstract read
In one paragraph

Article in Clinical lymphoma, myeloma & leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Sweet's Syndrome as a Prodromal Manifestation of Acute Myeloid Leukemia.International journal of hematology-oncology and stem cell research · 2025
    Article
  7. Acute myeloid leukemia withThe Journal of international medical research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Bullous Sweet Syndrome.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2022
    Article
  20. New Practical Aspects of Sweet Syndrome.American journal of clinical dermatology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Syed M Kazmi *Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Naveen Pemmaraju *Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Keyur P PatelDepartment of Hematopathology, University of Texas MD Anderson Cancer Center, TX, USA.
Philip R CohenDivision of Dermatology, University of California San Diego, San Diego, CA, USA.
Naval DaverDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kathy M TranDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Farhad RavandiDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Madeleine DuvicDepartment of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Guillermo Garcia-ManeroDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sherry PierceDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aziz NazhaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gautam BorthakurDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hagop KantarjianDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jorge CortesDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USUniversity of California, San Diego · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS CA016672NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

introductionSweet syndrome (SS) is associated with hematologic malignancies including acute myeloid leukemia (AML). PATIENTS AND

methodsRecords of patients with AML treated at our institution were reviewed to identify those with SS. Patient characteristics, laboratory values, and cytogenetic and molecular abnormalities were retrospectively reviewed.

resultsWe identified 21 of 2178 (1%) AML patients who demonstrated clinical signs and symptoms, and histological features consistent with SS. Eleven patients (52%) were classified as AML with myelodysplasia-related features and 3 patients had therapy-related AML. Three patients had received treatment with granulocyte colony stimulation factor, 1 patient liposomal all-trans-retinoic acid, and 2 patients received hypomethylating agents before development of SS. Cytogenetic analysis revealed diploid karyotype in 7 patients (33%); -5/del(5q) in 8 patients (38%): 3 patients had -5/del(5q) as the sole abnormality and 5 patients had -5/del(5q) as part of complex cytogenetics; and complex cytogenetics in 5 patients (24%). Gene mutations in FMS-related tyrosine kinase-3 (FLT3) gene were identified in 7 of 18 evaluable patients (39%), including FLT3-internal tandem duplication in 4 patients and FLT3-D835 tyrosine kinase domain mutation in 3 patients.

conclusionSS occurs in 1% of AML patients; -5/del(5q) karyotype, FLT3 mutations, and AML with myelodysplasia-related features were more frequent among patients with SS.

Indexed as

Sequence DeletionAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBase SequenceBone MarrowChromosomes, Human, Pair 5Cytogenetic AnalysisFemalefms-Like Tyrosine Kinase 3Granulocyte Colony-Stimulating FactorHumansKaryotypeLeukemia, Myeloid, AcuteMaleFLT3 protein, humanfms-Like Tyrosine Kinase 3Granulocyte Colony-Stimulating Factor−5/del(5q)Acute febrile neutrophilic dermatosisFMS-related tyrosine kinase-3Myelodysplastic syndromeNeutrophilic dermatosis

Identifiers

PMID25630528
PMCPMC4457594
OpenAlexW1983754464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.