ArticleBioorganic & medicinal chemistry2015
MCR synthesis of a tetracyclic tetrazole scaffold.
Article in Bioorganic & medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators.Journal of medicinal chemistry · 2024Article
- Supported Gold Nanoparticle-Catalyzed Selective Reduction of Multifunctional, Aromatic Nitro Precursors into Amines and Synthesis of 3,4-Dihydroquinoxalin-2-Ones.Molecules (Basel, Switzerland) · 2022Article
- The Pictet-Spengler Reaction Updates Its Habits.Molecules (Basel, Switzerland) · 2020Review
- Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model.ACS chemical neuroscience · 2019Article
- Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.Organic letters · 2019Article
- Tetrazoles via Multicomponent Reactions.Chemical reviews · 2019Review
- Article
- Recent advances in the application of indoles in multicomponent reactions.RSC advances · 2018Review
- Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction.ACS combinatorial science · 2017Article
- Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions).Molecules (Basel, Switzerland) · 2017Article
- Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations.ACS combinatorial science · 2017Article
- α-Amino Acid-Isosteric α-Amino Tetrazoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.Frontiers in medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on the Ugi tetrazole synthesis we have designed novel bi- and tri-cyclic scaffolds featuring interesting pharmacophore properties. The compounds of the scaffold (B) are synthesizable in large diversity and numbers in two steps using (hetero)phenylethylamines, HN3, oxo components and iscyanoacetaldehyde(dimethylacetale). The chemistry is amenable to parallel synthesis and is used to enhance and fill the screening decks of the European Lead factory (ELF). Here, we are reporting full experimental details, scope and limitations of the reaction, cheminformatic analysis and the 3D structures of selected compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.