Trial reportResuscitation2015
Target temperature management of 33°C and 36°C in patients with out-of-hospital cardiac arrest with initial non-shockable rhythm - a TTM sub-study.
Trial report in Resuscitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- [Targeted temperature management after cardiac arrest : What is new?]Der Anaesthesist · 2022Pooled it
- Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in medicine · 2022Pooled it
- Induced Hypothermia in Patients with Cardiac Arrest and a Non-shockable Rhythm: Meta-analysis and Trial Sequential Analysis.Neurocritical care · 2021Pooled it
- Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care.Critical care (London, England) · 2020Trial
- Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Trial
- Outcomes of Patients From All-Japan Utstein Registry Managed by 2015 Cardiopulmonary Resuscitation Guidelines for Nonshockable Out-of-Hospital Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Use of SOFA score in cardiac arrest research: A scoping review.Resuscitation plus · 2020Article
- [Focus general intensive care medicine : Intensive medical care studies from 2019/2020].Der Anaesthesist · 2020Article
- Targeted temperature management in cardiac arrest patients with a non-shockable rhythm: A national perspective.American heart journal · 2020Article
- [Targeted temperature management for cardiac arrest with nonshockable rhythm].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Article
- Resuscitating the Globally Ischemic Brain: TTM and Beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Targeted Temperature Management After Cardiac Arrest: The Montreal Heart Institute Experience.CJC open · 2019Article
- The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Association Between Therapeutic Hypothermia and Outcomes in Patients with Non-shockable Out-of-Hospital Cardiac Arrest Developed After Emergency Medical Service Arrival (SOS-KANTO 2012 Analysis Report).Neurocritical care · 2019Article
- Non-Coding RNAs to Aid in Neurological Prognosis after Cardiac Arrest.Non-coding RNA · 2018Review
- Does temperature management improve outcome in patients resuscitated from a non-shockable rhythm?Journal of thoracic disease · 2017Article
- Early predictors of poor outcome after out-of-hospital cardiac arrest.Critical care (London, England) · 2017Article
- What can a simple measure of heart rate during temperature management tell us on the physiology and prognosis of comatose cardiac arrest patients?Journal of thoracic disease · 2016Article
- Relationship Between the Duration of Cardiopulmonary Resuscitation and Favorable Neurological Outcomes After Out-of-Hospital Cardiac Arrest: A Prospective, Nationwide, Population-Based Cohort Study.Journal of the American Heart Association · 2016Observational
- Out-of-hospital cardiac arrest: the prospect of E-CPR in the Maastricht region.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
Corrections and comments
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Authors and funding
18 authors at 13 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite a lack of randomized trials in comatose survivors of out-of-hospital cardiac arrest (OHCA) with an initial non-shockable rhythm (NSR), guidelines recommend induced hypothermia to be considered in these patients. We assessed the effect on outcome of two levels of induced hypothermia in comatose patient resuscitated from NSR.
methodsHundred and seventy-eight patients out of 950 in the TTM trial with an initial NSR were randomly assigned to targeted temperature management at either 33°C (TTM33, n=96) or 36°C (TTM36, n=82). We assessed mortality, neurologic function (Cerebral Performance Score (CPC) and modified Rankin Scale (mRS)), and organ dysfunction (Sequential Organ Failure Assessment (SOFA) score).
resultsPatients with NSR were older, had longer time to ROSC, less frequently had bystander CPR and had higher lactate levels at admission compared to patients with shockable rhythm, p<0.001 for all. Mortality in patients with NSR was 84% in both temperature groups (unadjusted HR 0.92, adjusted HR 0.75; 95% CI 0.53-1.08, p=0.12). In the TTM33 group 3% survived with poor neurological outcome (CPC 3-4, mRS 4-5), compared to 2% in the TTM36 group (adjusted OR 0.67; 95% CI 0.08-4.73, p=0.69 for both). Thirteen percent in the TTM33 group and 15% in the TTM36 group had good neurologic outcome (CPC 1-2, mRS 0-3, OR 1.5, CI 0.21-12.5, p=0.69). The SOFA-score did not differ between temperature groups.
conclusionComatose patients after OHCA with initial NSR continue to have a poor prognosis. We found no effect of targeted temperature management at 33°C compared to 36°C in these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.