ArticleJournal of reconstructive microsurgery2015
Long-term functional recovery after facial nerve transection and repair in the rat.
Article in Journal of reconstructive microsurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Facial Nerve Repair: Bioengineering Approaches in Preclinical Models.Tissue engineering. Part B, Reviews · 2022Review
- Anatomical description of the extratemporal facial nerve under high-definition system: a microsurgical study in rats.Acta cirurgica brasileira · 2022Article
- Effect of Motor versus Sensory Nerve Autografts on Regeneration and Functional Outcomes of Rat Facial Nerve Reconstruction.Scientific reports · 2019Article
- Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy.The journal of international advanced otology · 2019Article
- Endogenous automatic nerve discharge promotes nerve repair: an optimized animal model.Neural regeneration research · 2019Article
- Toward the Bionic Face: A Novel Neuroprosthetic Device Paradigm for Facial Reanimation Consisting of Neural Blockade and Functional Electrical Stimulation.Plastic and reconstructive surgery · 2019Article
- Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair.Journal of tissue engineering and regenerative medicine · 2018Article
- Phrenic and intercostal nerves with rhythmic discharge can promote early nerve regeneration after brachial plexus repair in rats.Neural regeneration research · 2018Article
- Functional and Molecular Characterization of a Novel Traumatic Peripheral Nerve-Muscle Injury Model.Neuromolecular medicine · 2017Article
- Facial Nerve Recovery in KbDb and C1q Knockout Mice: A Role for Histocompatibility Complex 1.Plastic and reconstructive surgery. Global open · 2016Article
- Biodegradable Nerve Guide with Glial Cell Line-Derived Neurotrophic Factor Improves Recovery After Facial Nerve Injury in Rats.Facial plastic surgery & aesthetic medicineArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe rodent model is commonly used to study facial nerve injury. Because of the exceptional regenerative capacity of the rodent facial nerve, it is essential to consider the timing when studying facial nerve regeneration and functional recovery. Short-term functional recovery data following transection and repair of the facial nerve has been documented by our laboratory. However, because of the limitations of the head fixation device, there is a lack of long-term data following facial nerve injury. The objective of this study was to elucidate the long-term time course and functional deficit following facial nerve transection and repair in a rodent model.
methodsAdult rats were divided into group 1 (controls) and group 2 (experimental). Group 1 animals underwent head fixation, followed by a facial nerve injury, and functional testing was performed from day 7 to day 70. Group 2 animals underwent facial nerve injury, followed by delayed head fixation, and then underwent functional testing from months 6 to 8.
resultsThere was no statistical difference between the average whisking amplitudes in group 1 and group 2 animals.
conclusionFunctional whisking recovery 6 months after facial nerve injury is comparable to recovery within 1 to 4 months of transection and repair, thus the ideal window for evaluating facial nerve recovery falls within the 4 months after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.