Evidence map›Paper›PMID 25628894›Full record

ArticleJournal of ophthalmology2015

Evaluation of four genetic variants in han chinese subjects with high myopia.

Zimeng Ye, Huaichao Luo, Bo Gong, Ying Lin, Ping Shuai, Pu Wang, Changning Ye, Zhenglin Yang, Wanjun Wang, Yi Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zimeng YeCollege of Life Science and Engineering, Southwest Jiaotong University, 111, First Section, Northern Second Ring Road, Chengdu, Sichuan 610031, China ; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Huaichao LuoSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Bo GongSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; Department of Laboratory Medicine, Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Ying LinSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; Department of Laboratory Medicine, Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Ping ShuaiSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Pu WangSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Changning YeDepartment of Laboratory Medicine, Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; Department of Laboratory Medicine, Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; School of Medicine, University of Electronic Science and Technology of China, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
Wanjun WangCollege of Life Science and Engineering, Southwest Jiaotong University, 111, First Section, Northern Second Ring Road, Chengdu, Sichuan 610031, China.
Yi ShiSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; Department of Laboratory Medicine, Sichuan Provincial People's Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China ; School of Medicine, University of Electronic Science and Technology of China, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China.
University of Electronic Science and Technology of China · CNSouthwest Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High myopia is one of the leading causes of blindness worldwide. However, the exact etiology of high myopia remains unraveled despite numerous attempts of elucidation. Previous genome-wide association study (GWAS) has revealed that four single nucleotide polymorphisms (SNPs), including rs2969180, rs1652333, rs9307551, and rs7837791, were associated with high myopia in Caucasians. The present study was conducted to investigate whether these genetic variants were associated with high myopia in Han Chinese. These four SNPs were genotyped by SNaPshot method in a Han Chinese cohort composed of 827 patients with high myopia and 988 healthy controls. Among the SNPs genotyped, only rs9307551 was found to be significantly associated with high myopia in this study. Carriers of rs9307551A allele, AA, and AC genotypes had an increased risk of high myopia (OR = 1.33, 95% CI 1.14-1.54; OR = 1.75, 95% CI 1.28-2.38; OR = 1.59, 95% CI 1.24-2.01, resp.). Interestingly, when split by gender, the association between rs9307551 and high myopia proved to be gender-specific with significance observed only in females but not males. These findings suggested that the SNP of rs9307551 showed a gender-specific association with high myopia in the Han Chinese population. In addition, LOC100506035, a lincRNA gene, might play a crucial role in the susceptibility to high myopia.

Identifiers

PMID25628894
PMCPMC4300030
OpenAlexW2024848336

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.