ArticleMiddle East journal of digestive diseases2015
Direct Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer.
Article in Middle East journal of digestive diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Is Cyclooxygenase 2 Effective in Breast Cancer Diagnosis?Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case-control study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- An Increased Level of Aryl Hydrocarbon Receptor in Patients with Pancreatic Cancer.Middle East journal of digestive diseases · 2019Article
- Pancreatic Cancer is Associated with Peripheral Leukocyte Oxidative DNA DamageAsian Pacific journal of cancer prevention : APJCP · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND There are hoarding documents for the biological importance of cyclooxygenase-2 (COX-2) in pancreatic carcinogenesis. We aimed to thoroughly investigate the DNA sequence variations of whole COX-2 exons in a large case-control study of pancreatic cancer by direct sequencing. METHODS The entire exonic regions of COX-2 including 10 exons were sequenced in the germline DNA of 96 patients with pancreatic cancer. Selected variants within exons six to seven (E6E7) amplicon from the test panel were genotyped in 96 controls. RESULTS The COX-2 gene was demonstrated to be genetically conserved. Four missense mutations were found in three cases. However the common variant c.724-10_724-7delATTT (rs201231411) that is located in intron 6, showed significant difference between cases and controls (21 [21.9%] vs 11 [%11.5], p=0.05). CONCLUSION This study determined that COX-2 has a conservative sequence, which is required for its enzymatic activity and supports the important role of this enzyme's expression in pancreatic cancer rather than any changes in its activity. The effect of intronic variant rs201231411 on COX-2 expression could be analyzed in future studies.
Indexed as
Identifiers
25628848PMC4293795W2108854868What OpenQuestion holds
Registered trials
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