ArticleFrontiers in zoology2015
Myoinhibitory peptide regulates feeding in the marine annelid Platynereis.
Article in Frontiers in zoology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 148 citations in OpenAlex.
- Effects of food availability on larval development during ontogenetic niche shift in a marine annelid.Open biology · 2025Article
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- Microalgal biofilm induces larval settlement in the model marine wormRoyal Society open science · 2024Article
- Identification of the principal neuropeptide MIP and its action pathway in larval settlement of the echiuran worm Urechis unicinctus.BMC genomics · 2024Article
- The development of the adult nervous system in the annelid Owenia fusiformis.Neural development · 2024Article
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- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins.Frontiers in endocrinology · 2021Article
- Identification of the neuropeptide precursor genes potentially involved in the larval settlement in the Echiuran worm Urechis unicinctus.BMC genomics · 2020Article
- Identification, Localization in the Central Nervous System and Novel Myostimulatory Effect of Allatostatins inInternational journal of molecular sciences · 2020Article
- Function and Distribution of the Wamide Neuropeptide Superfamily in Metazoans.Frontiers in endocrinology · 2020Review
- A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae ofFrontiers in zoology · 2019Article
- Developmental studies provide new insights into the evolution of sense organs in Sabellariidae (Annelida).BMC evolutionary biology · 2018Article
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- Reference genes validation in Phenacoccus solenopsis under various biotic and abiotic stress conditions.Scientific reports · 2017Article
- Development of the nervous system inFrontiers in zoology · 2017Article
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- Localization of Neuropeptide Gene Expression in Larvae of an Echinoderm, the StarfishFrontiers in neuroscience · 2016Article
- Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein.Journal of the American Chemical Society · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring larval settlement and metamorphosis, marine invertebrates undergo changes in habitat, morphology, behavior and physiology. This change between life-cycle stages is often associated with a change in diet or a transition between a non-feeding and a feeding form. How larvae regulate changes in feeding during this life-cycle transition is not well understood. Neuropeptides are known to regulate several aspects of feeding, such as food search, ingestion and digestion. The marine annelid Platynereis dumerilii has a complex life cycle with a pelagic non-feeding larval stage and a benthic feeding postlarval stage, linked by the process of settlement. The conserved neuropeptide myoinhibitory peptide (MIP) is a key regulator of larval settlement behavior in Platynereis. Whether MIP also regulates the initiation of feeding, another aspect of the pelagic-to-benthic transition in Platynereis, is currently unknown.
resultsHere, we explore the contribution of MIP to the regulation of feeding behavior in settled Platynereis postlarvae. We find that in addition to expression in the brain, MIP is expressed in the gut of developing larvae in sensory neurons that densely innervate the hindgut, the foregut, and the midgut. Activating MIP signaling by synthetic neuropeptide addition causes increased gut peristalsis and more frequent pharynx extensions leading to increased food intake. Conversely, morpholino-mediated knockdown of MIP expression inhibits feeding. In the long-term, treatment of Platynereis postlarvae with synthetic MIP increases growth rate and results in earlier cephalic metamorphosis.
conclusionsOur results show that MIP activates ingestion and gut peristalsis in Platynereis postlarvae. MIP is expressed in enteroendocrine cells of the digestive system suggesting that following larval settlement, feeding may be initiated by a direct sensory-neurosecretory mechanism. This is similar to the mechanism by which MIP induces larval settlement. The pleiotropic roles of MIP may thus have evolved by redeploying the same signaling mechanism in different aspects of a life-cycle transition.
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