Evidence map›Paper›PMID 25628731›Full record

ReviewJournal of clinical neurology (Seoul, Korea)2015

Endovascular therapy for ischemic stroke.

Ramana M R Appireddy, Andrew M Demchuk, Mayank Goyal, Bijoy K Menon, Muneer Eesa, Philip Choi, Michael D Hill

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in Journal of clinical neurology (Seoul, Korea), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02603406 (Neovascularization Induced by Mechanical Barrier disrUption and Systemic Erythropoietin in Patients With Cerebral Perfusion Deficits), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02603406 phase2completednot on this mapstarted 2016, after this paper: background citation

Neovascularization Induced by Mechanical Barrier disrUption and Systemic Erythropoietin in Patients With Cerebral Perfusion Deficits (NIMBUS Trial)

TypeinterventionalSponsorAjou University School of MedicineRan2016 to 2019Enrolled44ConditionsAngiogenesis, Ischemic StrokeArmserythropoietin
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. A novel mechanism of neuroprotection: Blood glutamate grabber.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016
    Review
  8. Acute ischemic stroke imaging: a practical approach for diagnosis and triage.The international journal of cardiovascular imaging · 2016
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ramana M R AppireddyDepartment of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Andrew M DemchukDepartments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Mayank GoyalDepartments of Clinical Neurosciences and Radiology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Bijoy K MenonDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Muneer EesaDepartment of Radiology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Philip ChoiDepartment of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
Michael D HillDepartments of Clinical Neurosciences, Medicine, Radiology, and Community Health Sciences, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAAllen Institute for Brain Science · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The utility of intravenous tissue plasminogen activator (IV t-PA) in improving the clinical outcomes after acute ischemic stroke has been well demonstrated in past clinical trials. Though multiple initial small series of endovascular stroke therapy had shown good outcomes as compared to IV t-PA, a similar beneficial effect had not been translated in multiple randomized clinical trials of endovascular stroke therapy. Over the same time, there have been parallel advances in imaging technology and better understanding and utility of the imaging in therapy of acute stroke. In this review, we will discuss the evolution of endovascular stroke therapy followed by a discussion of the key factors that have to be considered during endovascular stroke therapy and directions for future endovascular stroke trials.

Indexed as

endovascular therapymechanical thrombectomystroke

Identifiers

PMID25628731
PMCPMC4302170
OpenAlexW2150360466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.