ReviewFrontiers in genetics2014
Condensin-mediated chromosome organization and gene regulation.
Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains.Nature structural & molecular biology · 2026Article
- Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans.PLoS genetics · 2025Article
- Transcriptional repression during spermatogenesis inmicroPublication biology · 2023Article
- The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding.Journal of cell science · 2022Article
- Article
- Analysis of Hi-C data using SIP effectively identifies loops in organisms fromGenome research · 2020Article
- Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression inGenetics · 2018Article
- Condensin I protects meiotic cohesin from WAPL-1 mediated removal.PLoS genetics · 2018Article
- Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.Trends in genetics : TIG · 2018Review
- Article
- An SMC-like protein binds and regulates Caenorhabditis elegans condensins.PLoS genetics · 2017Article
- The functional role for condensin in the regulation of chromosomal organization during the cell cycle.Cellular and molecular life sciences : CMLS · 2016Review
- Anchoring of Heterochromatin to the Nuclear Lamina Reinforces Dosage Compensation-Mediated Gene Repression.PLoS genetics · 2016Article
- An H4K16 histone acetyltransferase mediates decondensation of the X chromosome inEpigenetics & chromatin · 2016Article
- Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans.PLoS genetics · 2015Article
- The expanding territories of condensin II.Cell cycle (Georgetown, Tex.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation is achieved by the dosage compensation complex (DCC) binding to both X chromosomes in hermaphrodites to downregulate gene expression by twofold. The DCC contains a subcomplex (condensin I(DC)) similar to the evolutionarily conserved condensin complexes which play a fundamental role in chromosome dynamics during mitosis. Therefore, mechanisms related to mitotic chromosome condensation are hypothesized to mediate dosage compensation. Consistent with this hypothesis, monomethylation of histone H4 lysine 20 is increased, whereas acetylation of histone H4 lysine 16 is decreased, both on mitotic chromosomes and on interphase dosage compensated X chromosomes in worms. These observations suggest that interphase dosage compensated X chromosomes maintain some characteristics associated with condensed mitotic chromosome. This chromosome state is stably propagated from one cell generation to the next. In this review we will speculate on how the biochemical activities of condensin can achieve both mitotic chromosome compaction and gene repression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.