Evidence map›Paper›PMID 25628617›Full record

ArticleFrontiers in microbiology2014

Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance.

Dimitry A Chistiakov, Yuri V Bobryshev, Emil Kozarov, Igor A Sobenin, Alexander N Orekhov

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
  2. Review
  3. When Checkpoint Inhibitors Break Barriers: Mechanisms and Challenges of irAEs of the Skin, Gastrointestinal Tract, and Lung.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  4. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dimitry A ChistiakovDepartment of Medical Nanobiotechnology, Pirogov Russian State Medical University , Moscow, Russia ; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center , Miami Beach, FL, USA ; Research Center for Children's Health , Moscow, Russia.
Yuri V BobryshevInstitute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales , Sydney, NSW, Australia ; School of Medicine, University of Western Sydney , Campbelltown, NSW, Australia.
Emil KozarovDepartment of Oral and Diagnostic Sciences, Columbia University , New York, NY, USA.
Igor A SobeninInstitute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia ; Department of Oral and Diagnostic Sciences, Columbia University , New York, NY, USA ; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex , Moscow, Russia.
Alexander N OrekhovInstitute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal tolerance.

Indexed as

harmful antigensimmune systemintestinal microbiotamicrofloratolerance

Identifiers

PMID25628617
PMCPMC4292724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.