ArticleFrontiers in neurology2014
Changes in chronotype after stroke: a pilot study.
Article in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Chronotherapy to reinforce circadian rhythms improves poststroke outcomes and glymphatic function in mice.The Journal of clinical investigation · 2026Article
- Study on the relationship between sleep-wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke.Frontiers in neurology · 2025Article
- Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study.EClinicalMedicine · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- Effects of surgery and general anaesthesia on sleep-wake timing: CLOCKS observational study.Anaesthesia · 2022Observational
- Narrative review of sleep and stroke.Journal of thoracic disease · 2020Review
- Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2019Review
- Sleep-Wake Disorders in Stroke-Increased Stroke Risk and Deteriorated Recovery? An Evaluation on the Necessity for Prevention and Treatment.Current neurology and neuroscience reports · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to elucidate associations between stroke onset and severity as well as chronotype (phase of entrainment) and internal time of stroke. Fifty-six first-ever ischemic stroke patients participated in a cross-sectional study assessing chronotype (mid-sleep on work-free days corrected for sleep deficit on workdays; MSFsc) by applying the Munich ChronoType Questionnaire (MCTQ). The MCTQ was completed twice, on average 68 ± 24 (SD) days post stroke and retrospectively for the time before stroke. To assess the impact of stroke in relation to internal time, InTstroke was calculated as MSFsc minus local time of stroke. Stroke severity was assessed via the standard clinical National Institute Health Stroke Scale (NIHSS) and modified Ranking Scale (mRS), both at hospital admission and discharge. Overall, most strokes occurred between noon and midnight. There was no significant association between MSFsc and stroke onset. MSFsc changed significantly after stroke, especially in patients with more severe strokes. Changes in MSFsc varied with InTstroke - the earlier the internal time of a stroke relative to MSFsc-before-stroke, the more MSFsc advanced after stroke. In addition, we provide first evidence that MSFsc changes varied between stroke locations. Larger trials are needed to confirm these findings.
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Registered trials
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