ReviewFrontiers in human neuroscience2014
Approaching a network connectivity-driven classification of the psychosis continuum: a selective review and suggestions for future research.
Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Dopamine-Induced Dysconnectivity Between Salience Network and Auditory Cortex in Subjects With Psychotic-like Experiences: A Randomized Double-Blind Placebo-Controlled Study.Schizophrenia bulletin · 2020Trial
- Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.Human brain mapping · 2019Trial
- Schizotypal Traits are Linked to Dopamine-Induced Striato-Cortical Decoupling: A Randomized Double-Blind Placebo-Controlled Study.Schizophrenia bulletin · 2019Trial
- Trial
- Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning.Schizophrenia (Heidelberg, Germany) · 2026Article
- Influence of noninvasive brain stimulation on connectivity and local activation: a combined tDCS and fMRI study.European archives of psychiatry and clinical neuroscience · 2024Article
- Interperformer coordination in piano-singing duo performances: phrase structure and empathy impact.Psychological research · 2023Article
- Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.Biological psychiatry global open science · 2023Article
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode.International journal of environmental research and public health · 2022Article
- Characterization of Hemodynamic Alterations in Schizophrenia and Bipolar Disorder and Their Effect on Resting-State fMRI Functional Connectivity.Schizophrenia bulletin · 2022Article
- Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients.Frontiers in psychiatry · 2022Article
- Hypersensitivity to passive voice hearing in hallucination proneness.Frontiers in human neuroscience · 2022Article
- Functional connectome differences in individuals with hallucinations across the psychosis continuum.Scientific reports · 2021Article
- Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis.NPJ schizophrenia · 2020Article
- Aberrant static and dynamic functional patterns of frontoparietal control network in antipsychotic-naïve first-episode psychosis subjects.Human brain mapping · 2020Article
- Brain gray matter network organization in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.Biological psychiatry · 2019Article
- Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease onset and proceeding with ongoing illness. Recent investigations have focused attention on functional brain interactions, with experimental imaging studies supporting the disconnection hypothesis of schizophrenia. These studies have revealed a broad spectrum of abnormalities in brain connectivity in patients, particularly for connections integrating the frontal cortex. A critical point is that brain connectivity abnormalities, including altered resting state connectivity within the fronto-parietal (FP) network, are already observed in non-help-seeking individuals with psychotic-like experiences. If we consider psychosis as a continuum, with individuals with psychotic-like experiences at the lower and psychotic patients at the upper ends, individuals with psychotic-like experiences represent a key population for investigating the validity of putative biomarkers underlying the onset of psychosis. This paper selectively addresses the role played by FP connectivity in the psychosis continuum, which includes patients with chronic psychosis, early psychosis, clinical high risk, genetic high risk, as well as the general population with psychotic experiences. We first discuss structural connectivity changes among the FP pathway in each domain in the psychosis continuum. This may provide a basis for us to gain an understanding of the subsequent changes in functional FP connectivity. We further indicate that abnormal FP connectivity may arise from glutamatergic disturbances of this pathway, in particular from abnormal NMDA receptor-mediated plasticity. In the second part of this paper we propose some concepts for further research on the use of network connectivity in the classification of the psychosis continuum. These concepts are consistent with recent efforts to enhance the role of data in driving the diagnosis of psychiatric spectrum diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.