ArticleFrontiers in behavioral neuroscience2014
A novel behavioral paradigm to assess multisensory processing in mice.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs.Current biology : CB · 2025Article
- Assessing the impact of monocular deprivation on visual evoked potentials, behavior, and visual plasticity in juvenile mice.Annals of translational medicine · 2022Article
- Cupid's quiver: Integrating sensory cues in rodent mating systems.Frontiers in neural circuits · 2022Review
- Auditory input enhances somatosensory encoding and tactile goal-directed behavior.Nature communications · 2021Article
- Behavioral Approaches to Study Top-Down Influences on Active Listening.Frontiers in neuroscience · 2021Article
- Approaches to Understanding Multisensory Dysfunction in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Review
- Monocular and binocular opto-locomotor reflex biases for random dot motion in mice.Journal of vision · 2020Article
- Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain.Frontiers in neurorobotics · 2020Review
- Auditory-induced visual illusions in rodents measured by spontaneous behavioural response.Scientific reports · 2019Article
- An insular view of the social decision-making network.Neuroscience and biobehavioral reviews · 2019Review
- Adult-Onset Hearing Impairment Induces Layer-Specific Cortical Reorganization: Evidence of Crossmodal Plasticity and Central Gain Enhancement.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The opto-locomotor reflex as a tool to measure sensitivity to moving random dot patterns in mice.Scientific reports · 2018Article
- Behavioral Plasticity of Audiovisual Perception: Rapid Recalibration of Temporal Sensitivity but Not Perceptual Binding Following Adult-Onset Hearing Loss.Frontiers in behavioral neuroscience · 2018Article
- An autism-associated serotonin transporter variant disrupts multisensory processing.Translational psychiatry · 2017Article
- Audio-Visual Integration in a Redundant Target Paradigm: A Comparison between Rhesus Macaque and Man.Frontiers in systems neuroscience · 2017Article
- Audiovisual Temporal Processing and Synchrony Perception in the Rat.Frontiers in behavioral neuroscience · 2016Article
- Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder.Progress in neurobiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Human psychophysical and animal behavioral studies have illustrated the benefits that can be conferred from having information available from multiple senses. Given the central role of multisensory integration for perceptual and cognitive function, it is important to design behavioral paradigms for animal models to provide mechanistic insights into the neural bases of these multisensory processes. Prior studies have focused on large mammals, yet the mouse offers a host of advantages, most importantly the wealth of available genetic manipulations relevant to human disease. To begin to employ this model species for multisensory research it is necessary to first establish and validate a robust behavioral assay for the mouse. Two common mouse strains (C57BL/6J and 129S6/SvEv) were first trained to respond to unisensory (visual and auditory) stimuli separately. Once trained, performance with paired audiovisual stimuli was then examined with a focus on response accuracy and behavioral gain. Stimulus durations varied from 50 ms to 1 s in order to modulate the effectiveness of the stimuli and to determine if the well-established "principle of inverse effectiveness" held in this model. Response accuracy in the multisensory condition was greater than for either unisensory condition for all stimulus durations, with significant gains observed at the 300 ms and 100 ms durations. Main effects of stimulus duration, stimulus modality and a significant interaction between these factors were observed. The greatest behavioral gain was seen for the 100 ms duration condition, with a trend observed that as the stimuli became less effective, larger behavioral gains were observed upon their pairing (i.e., inverse effectiveness). These results are the first to validate the mouse as a species that shows demonstrable behavioral facilitations under multisensory conditions and provides a platform for future mechanistically directed studies to examine the neural bases of multisensory integration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.