ArticleFrontiers in neuroscience2014
Neonatal overfeeding attenuates acute central pro-inflammatory effects of short-term high fat diet.
Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Adolescent high fat diet alters the transcriptional response of microglia in the prefrontal cortex in response to stressors in both male and female mice.Stress (Amsterdam, Netherlands) · 2024Article
- Mapping of Microglial Brain Region, Sex and Age Heterogeneity in Obesity.International journal of molecular sciences · 2021Review
- The Effect of Short-Term Feeding of a High-Coconut Oil or High-Fat Diet on Neuroinflammation and the Performance of an Object-Place Task in Rats.Neurochemical research · 2021Article
- Article
- Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.Experimental gerontology · 2020Review
- High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner.Neurobiology of aging · 2019Article
- Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue.Bioscience reports · 2018Article
- Small litter size impairs spatial memory and increases anxiety- like behavior in a strain-dependent manner in male mice.Scientific reports · 2018Article
- Microglia activation due to obesity programs metabolic failure leading to type two diabetes.Nutrition & diabetes · 2017Review
- The initiation of metabolic inflammation in childhood obesity.The Journal of clinical investigation · 2017Review
- Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning.Journal of neuroinflammation · 2016Article
- Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.Scientific reports · 2016Article
- Hypothalamic inflammation and gliosis in obesity.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Editorial: Neuroinflammation and behavior.Frontiers in neuroscience · 2015Article
- Article
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Authors and funding
11 authors.
Funding
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Abstract
Neonatal obesity predisposes individuals to obesity throughout life. In rats, neonatal overfeeding also leads to early accelerated weight gain that persists into adulthood. The phenotype is associated with dysfunction in a number of systems including paraventricular nucleus of the hypothalamus (PVN) responses to psychological and immune stressors. However, in many cases weight gain in neonatally overfed rats stabilizes in early adulthood so the animal does not become more obese as it ages. Here we examined if neonatal overfeeding by suckling rats in small litters predisposes them to exacerbated metabolic and central inflammatory disturbances if they are also given a high fat diet in later life. In adulthood we gave the rats normal chow, 3 days, or 3 weeks high fat diet (45% kcal from fat) and measured peripheral indices of metabolic disturbance. We also investigated hypothalamic microglial changes, as an index of central inflammation, as well as PVN responses to lipopolysaccharide (LPS). Surprisingly, neonatal overfeeding did not predispose rats to the metabolic effects of a high fat diet. Weight changes and glucose metabolism were unaffected by the early life experience. However, short term (3 day) high fat diet was associated with more microglia in the hypothalamus and a markedly exacerbated PVN response to LPS in control rats; effects not seen in the neonatally overfed. Our findings indicate neonatally overfed animals are not more susceptible to the adverse metabolic effects of a short-term high fat diet but may be less able to respond to the central effects.
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