Evidence map›Paper›PMID 25628407›Full record

ArticleJournal of the American Heart Association2015

Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake.

Jia Zhong, Elena Colicino, Xinyi Lin, Amar Mehta, Itai Kloog, Antonella Zanobetti, Hyang-Min Byun, Marie-Abèle Bind, Laura Cantone, Diddier Prada and 6 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Epigenetics and environmental health.Frontiers of medicine · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Djulis (Molecules (Basel, Switzerland) · 2021
    Article
  10. Review
  11. Inflammatory effects of particulate matter air pollution.Environmental science and pollution research international · 2020
    Review
  12. Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  13. Review
  14. In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children.Environmental epidemiology (Philadelphia, Pa.) · 2019
    Article
  15. Article
  16. Translational Perspective on Epigenetics in Cardiovascular Disease.Journal of the American College of Cardiology · 2017
    Review
  17. Article
  18. Article
  19. Article
  20. Associations between long-term exposure to PMEnvironment international · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Jia ZhongDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Elena ColicinoDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Xinyi LinDepartment of Biostatistics, Harvard School of Public Health, Boston, MA (X.L., M.A.B.) Singapore Institute for Clinical Sciences, Singapore (X.L.).
Amar MehtaDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Itai KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.).
Antonella ZanobettiDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Hyang-Min ByunDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Marie-Abèle BindDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.) Department of Biostatistics, Harvard School of Public Health, Boston, MA (X.L., M.A.B.).
Laura CantoneCenter of Molecular and Genetic Epidemiology, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy (L.C., L.T.).
Diddier PradaDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Letizia TarantiniCenter of Molecular and Genetic Epidemiology, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy (L.C., L.T.).
Letizia TrevisiDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
David SparrowVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA (D.S., P.V.).
Pantel VokonasVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA (D.S., P.V.).
Joel SchwartzDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Andrea A BaccarelliDepartment of Environmental Health, Harvard School of Public Health, Boston, MA (J.Z., E.C., A.M., A.Z., H.M.B., M.A.B., D.P., L.T., J.S., A.A.B.).
Harvard University · USUniversity of Milan · ITBen-Gurion University of the Negev · ILBoston University · USSingapore Institute for Clinical Sciences · SGVA Boston Healthcare System · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention TrialR21ES021895 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2013
$376k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01ES015172NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01ES021357NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R01ES021733NIEHS NIH HHS R21 ES021895NIEHS NIH HHS R21ES021895
6 · The paper itself

Abstract

backgroundShort-term fine particles (PM(2.5)) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility is essential for intervention. We evaluated whether Toll-like receptor 2 (TLR2) methylation, a reversible immune-epigenetic process, and its dietary modulation by flavonoids and methyl nutrients, modify susceptibility to heart rate variability effects following PM(2.5) exposure. METHODS AND

resultsWe measured heart rate variability and PM(2.5) repeatedly over 11 years (1275 total observations) among 573 elderly men from the Normative Aging Study. Blood TLR2 methylation was analyzed using pyrosequencing. Daily flavonoid and methyl nutrients intakes were assessed through the Food Frequency Questionnaire (FFQ). Every 10 μg/m(3) increase in 48-hour PM(2.5) moving average was associated with 7.74% (95% CI: -1.21% to 15.90%; P=0.09), 7.46% (95% CI: 0.99% to 13.50%; P=0.02), 14.18% (95% CI: 1.14% to 25.49%; P=0.03), and 12.94% (95% CI: -2.36% to 25.96%; P=0.09) reductions in root mean square of successive differences, standard deviation of normal-to-normal intervals, low-frequency power, and high-frequency power, respectively. Higher TLR2 methylation exacerbated the root mean square of successive differences, standard deviation of normal-to-normal intervals, low-frequency, and high-frequency reductions associated with heightened PM2.5 (P(interaction)=0.006, 0.03, 0.05, 0.04, respectively). Every interquartile-range increase in flavonoid intake was associated with 5.09% reduction in mean TLR2 methylation (95% CI: 0.12% to 10.06%; P=0.05) and counteracted the effects of PM2.5 on low frequency (P(interaction)=0.05). No significant effect of methyl nutrients on TLR2 methylation was observed.

conclusionsHigher TLR2 methylation may confer susceptibility to adverse cardiac autonomic effects of PM2.5 exposure in older individuals. Higher flavonoid intake may attenuate these effects, possibly by decreasing TLR2 methylation.

Indexed as

DietAgedAged, 80 and overAgingAutonomic Nervous System DiseasesBradycardiaCohort StudiesEpigenomicsFlavonoidsGeriatric AssessmentHeart Conduction SystemHumansImmunomodulationMaleMethylationParticulate MatterFlavonoidsParticulate MatterToll-Like Receptor 2epidemiologyepigeneticsheart rate variabilityinflammationnutrition

Identifiers

PMID25628407
PMCPMC4330067
OpenAlexW2155651014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.