The brain, amphotericin B, and P-glycoprotein.

David A Stevens, Karl V Clemons, Marife Martinez, Vicky Chen

Abstract readLetterComment

In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics.Frontiers in chemistry · 2021
Article
Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity.The AAPS journal · 2019
Review
Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients.Infection · 2017
Review
Reply to "the brain, amphotericin B, and p-glycoprotein".Antimicrobial agents and chemotherapy · 2015
Article

4 · The record

Corrections and comments

Commented on by
Reply to "the brain, amphotericin B, and p-glycoprotein".2015
Comment on
In vitro and in vivo evidence for amphotericin B as a P-glycoprotein substrate on the blood-brain barrier.2014

5 · Who and what money

Authors and funding

4 authors.

David A StevensDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA California Institute for Medical Research, San Jose, California, USA stevens@stanford.edu.

Karl V ClemonsDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA California Institute for Medical Research, San Jose, California, USA.

Marife MartinezCalifornia Institute for Medical Research, San Jose, California, USA.

Vicky ChenCalifornia Institute for Medical Research, San Jose, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amphotericin BAnimalsAntifungal AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierCryptococcosisMaleVerapamilAmphotericin BAntifungal AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Verapamil

Identifiers

PMID25628395

DOI10.1128/AAC.04768-14

PMCPMC4335912

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.