Evidence map›Paper›PMID 25628381›Full record

ArticleThe international journal of neuropsychopharmacology2014

Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.

Ji-chun Zhang, Jin Wu, Yuko Fujita, Wei Yao, Qian Ren, Chun Yang, Su-xia Li, Yukihiko Shirayama, Kenji Hashimoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 2 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 284 citations in OpenAlex.

  1. Pooled it
  2. What Animal Models Can Tell Us About Long-Term Psychiatric Symptoms in Sepsis Survivors: a Systematic Review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ji-chun ZhangDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Jin WuDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Yuko FujitaDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Wei YaoDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Qian RenDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Chun YangDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Su-xia LiDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Yukihiko ShirayamaDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
Kenji HashimotoDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama). hashimoto@faculty.chiba-u.jp.
Peking University · CNCenter for Forensic Mental Health, Chiba University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-induced model of depression.

methodsIn this study, we examined the effects of TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) and TrkB antagonist ANA-12 on depression-like behavior and morphological changes in mice previously exposed to lipopolysaccharide (LPS). Protein levels of BDNF, phospho-TrkB (p-TrkB), and TrkB in the brain regions were also examined.

resultsLPS caused a reduction of BDNF in the CA3 and dentate gyrus (DG) of the hippocampus and prefrontal cortex (PFC), whereas LPS increased BDNF in the nucleus accumbens (NAc). Dexamethason suppression tests showed hyperactivity of the hypothalamic-pituitary-adrenal axis in LPS-treated mice. Intraperitoneal (i.p.) administration of 7,8-DHF showed antidepressant effects on LPS-induced depression-like behavior, and i.p. pretreatment with ANA-12 blocked its antidepressant effects. Surprisingly, ANA-12 alone showed antidepressant-like effects on LPS-induced depression-like behavior. Furthermore, bilateral infusion of ANA-12 into the NAc showed antidepressant effects. Moreover, LPS caused a reduction of spine density in the CA3, DG, and PFC, whereas LPS increased spine density in the NAc. Interestingly, 7,8-DHF significantly attenuated LPS-induced reduction of p-TrkB and spine densities in the CA3, DG, and PFC, whereas ANA-12 significantly attenuated LPS-induced increases of p-TrkB and spine density in the NAc.

conclusionsThe results suggest that LPS-induced inflammation may cause depression-like behavior by altering BDNF and spine density in the CA3, DG, PFC, and NAc, which may be involved in the antidepressant effects of 7,8-DHF and ANA-12, respectively.

Indexed as

AnimalsAntidepressive AgentsAzepinesBenzamidesBrain-Derived Neurotrophic FactorDendritic SpinesDepressive DisorderDisease Models, AnimalFlavonesHippocampusLipopolysaccharidesMaleMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMultiprotein ComplexesNucleus Accumbens6,7-dihydroxyflavoneANA 12 compoundAntidepressive AgentsAzepinesBenzamidesBrain-Derived Neurotrophic FactorFlavonesLipopolysaccharidesMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesReceptor, trkBTOR Serine-Threonine KinasesBDNF-TrkB signalinghippocampusinflammationnucleus accumbensprefrontal cortex

Identifiers

PMID25628381
PMCPMC4360225
OpenAlexW2055018912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.