ArticleJournal of experimental botany2015
Imposed glutathione-mediated redox switch modulates the tobacco wound-induced protein kinase and salicylic acid-induced protein kinase activation state and impacts on defence against Pseudomonas syringae.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- QTL mapping for resistance to Pseudomonas syringae pv. actinidiae (Psa) in tetraploid Actinidia.BMC plant biology · 2025Article
- Immunocompromisation of wheat host by L-BSO and 2,4-DPA induces susceptibility to the fungal pathogen Fusarium oxysporum.Stress biology · 2024Article
- Organelle-targeted biosensors reveal distinct oxidative events during pattern-triggered immune responses.Plant physiology · 2023Article
- Article
- AtGSTU19 and AtGSTU24 as Moderators of the Response ofInternational journal of molecular sciences · 2022Article
- Intertwined Roles of Reactive Oxygen Species and Salicylic Acid Signaling Are Crucial for the Plant Response to Biotic Stress.International journal of molecular sciences · 2022Review
- MAPK Cascades and Transcriptional Factors: Regulation of Heavy Metal Tolerance in Plants.International journal of molecular sciences · 2022Review
- S-Nitrosoglutathione Reductase Contributes to Thermotolerance by Modulating High Temperature-Induced Apoplastic HFrontiers in plant science · 2022Article
- Glutathione contributes to resistance responses to TMV through a differential modulation of salicylic acid and reactive oxygen species.Molecular plant pathology · 2021Article
- Boosting of Antioxidants and Alkaloids inPlants (Basel, Switzerland) · 2021Article
- OXR2 Increases Plant Defense against a Hemibiotrophic Pathogen via the Salicylic Acid Pathway.Plant physiology · 2020Article
- Aspirin Eugenol Ester Attenuates Paraquat-Induced Hepatotoxicity by Inhibiting Oxidative Stress.Frontiers in physiology · 2020Article
- Deciphering hydrogen peroxide-induced signalling towards stress tolerance in plants.3 Biotech · 2019Review
- Glutathione Can Compensate for Salicylic Acid Deficiency in Tobacco to Maintain Resistance toFrontiers in plant science · 2019Article
- Hydrogen Sulfide-Mediated Activation ofInternational journal of molecular sciences · 2018Article
- Managing Competing Interests: Partitioning S between Glutathione and Protein Synthesis.Plant physiology · 2018Article
- A review of redox signaling and the control of MAP kinase pathway in plants.Redox biology · 2017Review
- Flavonoid Accumulation Plays an Important Role in the Rust Resistance ofFrontiers in plant science · 2017Article
- Expression Patterns of Genes Involved in Ascorbate-Glutathione Cycle in Aphid-Infested Maize (Zea mays L.) Seedlings.International journal of molecular sciences · 2016Article
- Transcriptome- Assisted Label-Free Quantitative Proteomics Analysis Reveals Novel Insights into Piper nigrum-Phytophthora capsici Phytopathosystem.Frontiers in plant science · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the redox-active tripeptide glutathione in plant defence against pathogens has been studied extensively; however, the impact of changes in cellular glutathione redox potential on signalling processes during defence reactions has remained elusive. This study explored the impact of elevated glutathione content on the cytosolic redox potential and on early defence signalling at the level of mitogen-activated protein kinases (MAPKs), as well as on subsequent defence reactions, including changes in salicylic acid (SA) content, pathogenesis-related gene expression, callose depositions, and the hypersensitive response. Wild-type (WT) Nicotiana tabacum L. and transgenic high-glutathione lines (HGL) were transformed with the cytosol-targeted sensor GRX1-roGFP2 to monitor the cytosolic redox state. Surprisingly, HGLs displayed an oxidative shift in their cytosolic redox potential and an activation of the tobacco MAPKs wound-induced protein kinase (WIPK) and SA-induced protein kinase (SIPK). This activation occurred in the absence of any change in free SA content, but was accompanied by constitutively increased expression of several defence genes. Similarly, rapid activation of MAPKs could be induced in WT tobacco by exposure to either reduced or oxidized glutathione. When HGL plants were challenged with adapted or non-adapted Pseudomonas syringae pathovars, the cytosolic redox shift was further amplified and the defence response was markedly increased, showing a priming effect for SA and callose; however, the initial and transient hyperactivation of MAPK signalling was attenuated in HGLs. The results suggest that, in tobacco, MAPK and SA signalling may operate independently, both possibly being modulated by the glutathione redox potential. Possible mechanisms for redox-mediated MAPK activation are discussed.
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