ArticleScientific reports2015
Apoptosis signal-regulating kinase 1 promotes Ochratoxin A-induced renal cytotoxicity.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Epigallocatechin-3-gallate as a hepatoprotective agent against ochratoxin a: modulating ER stress and NF-κB/TNF-α/IL-6 responses.Mycotoxin research · 2026Article
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- Ochratoxin A and Clear Cell Renal Cell Carcinoma: Exploring Potential Molecular Links Through Network Toxicology and Machine Learning.International journal of molecular sciences · 2026Article
- The Regulatory Mechanisms of Treponema pallidum Enolase on Macrophages: From Enzymatic Activity to Signal Transduction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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- Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.Apoptosis : an international journal on programmed cell death · 2025Article
- Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins.Archives of toxicology · 2025Article
- Review
- Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review.Frontiers in veterinary science · 2022Review
- Review
- Article
- Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence.International journal of molecular sciences · 2021Review
- Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis.Archives of toxicology · 2021Article
- Porous Silicon Optical Devices: Recent Advances in Biosensing Applications.Sensors (Basel, Switzerland) · 2021Review
- Single-cell transcriptomics uncovers potential marker genes of ochratoxin A-sensitive renal cells in an acute toxicity rat model.Cell biology and toxicology · 2021Article
- Biological Mechanisms Induced by Soybean Agglutinin Using an Intestinal Cell Model of Monogastric Animals.Frontiers in veterinary science · 2021Article
- Ochratoxin A-induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies.Environmental science and pollution research international · 2020Review
- Risk assessment of ochratoxin A in food.EFSA journal. European Food Safety Authority · 2020Article
- Transcriptome Analysis of Ochratoxin A-Induced Apoptosis in Differentiated Caco-2 Cells.Toxins · 2019Article
- Experimental ochratoxicosis A in Nile tilapia and its amelioration by some feed additives.International journal of veterinary science and medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 in HEK293 cells and employed an iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism of ASK1 in OTA-induced renal cytotoxicity. Our results showed that ASK1 knockdown alleviated OTA-induced ROS generation and Δψm loss and thus desensitized the cells to OTA-induced apoptosis. We identified 33 and 24 differentially expressed proteins upon OTA treatment in scrambled and ASK1 knockdown cells, respectively. Pathway classification and analysis revealed that ASK1 participated in OTA-induced inhibition of mRNA splicing, nucleotide metabolism, the cell cycle, DNA repair, and the activation of lipid metabolism. We concluded that ASK1 plays an essential role in promoting OTA-induced renal cytotoxicity.
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