ArticleHuman brain mapping2015
The intrinsic resting state voice network in Parkinson's disease.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Striatal network dysfunction underlying speech impairment in early Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Investigation of nonmotor symptoms and their clinical correlates in patients with Parkinson's disease.Neurodegenerative disease management · 2025Article
- Short-term effects of transcranial direct current stimulation on motor speech in Parkinson's disease: a pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Continuous theta burst stimulation over right cerebellum for speech impairment in Parkinson's disease: study protocol for a randomized, sham-controlled, clinical trial.Frontiers in aging neuroscience · 2023Article
- Cognitive profile of patients with and without speech impairment in Parkinson's disease.Dementia & neuropsychologia · 2023Article
- Analysis of Parkinson's Disease Using an Imbalanced-Speech Dataset by Employing Decision Tree Ensemble Methods.Diagnostics (Basel, Switzerland) · 2022Article
- Characterization of Mild and Moderate Dysarthria in Parkinson's Disease: Behavioral Measures and Neural Correlates.Frontiers in aging neuroscience · 2022Article
- Alterations of Regional Homogeneity in the Mild and Moderate Stages of Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Attention/memory complaint is correlated with motor speech disorder in Parkinson's disease.BMC neurology · 2019Article
- Classifying Parkinson's Disease Based on Acoustic Measures Using Artificial Neural Networks.Sensors (Basel, Switzerland) · 2018Article
- Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease.Brain and behavior · 2018Article
- Connectivity profiles of the insular network for speech control in healthy individuals and patients with spasmodic dysphonia.Brain structure & function · 2018Article
- Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?NeuroImage. Clinical · 2018Review
- On the integrity of functional brain networks in schizophrenia, Parkinson's disease, and advanced age: Evidence from connectivity-based single-subject classification.Human brain mapping · 2017Article
- Separate neural representations of depression, anxiety and apathy in Parkinson's disease.Scientific reports · 2017Article
- Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control.Human brain mapping · 2016Article
- Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control.Scientific reports · 2016Article
- Voxel-Wise Meta-Analysis of Gray Matter Changes in Amyotrophic Lateral Sclerosis.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
Over 90 percent of patients with Parkinson's disease experience speech-motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting-state functional connectivity analysis of blood oxygen level-dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting-state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta-analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender-, age-, and movement-matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ-39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within-group analyses of connectivity patterns demonstrated a lack of subcortical-cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.