ArticleInternational journal of cancer2015
Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.
Article in International journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Trial
- Nutritional Determinants of Oral Cancer: A Global Population Attributable Fraction Analysis Across 185 Countries (1990-2018).International dental journal · 2026Article
- From Carcinogenesis to Drug Resistance: The Multifaceted Role of Oxidative Stress in Head and Neck Cancer.Cancers · 2025Review
- Oxidative Stress and Dietary Antioxidants in Head and Neck Cancer.Antioxidants (Basel, Switzerland) · 2025Review
- Beyond Conventional Treatments: The Role of Complementary Therapies in Head and Neck Cancer.Cancers · 2025Review
- Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study.Food & nutrition research · 2025Article
- Association between the Mediterranean Diet and Vitamin C and the Risk of Head and Neck Cancer.Nutrients · 2023Article
- Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art.Journal of clinical medicine · 2023Review
- Intake of prebiotic fibers and the risk of laryngeal cancer: the PrebiotiCa study.European journal of nutrition · 2023Article
- Evolution of the Incidence of Oral Cavity Cancers in the Elderly from 1990 to 2018.Journal of clinical medicine · 2023Article
- Article
- Relationship Between Dietary Fiber and Vitamin C Intake and Oral Cancer.Frontiers in public health · 2022Article
- Association between Oral Cancer and Diet: An Update.Nutrients · 2021Review
- Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.Oral diseases · 2021Review
- Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health.Frontiers in nutrition · 2021Article
- Reproducibility of A Posteriori Dietary Patterns across Time and Studies: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2020Article
- Do COJournal of enzyme inhibition and medicinal chemistry · 2019Article
- Fish/shellfish intake and the risk of head and neck cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019Article
- Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium.Epidemiology (Cambridge, Mass.) · 2019Article
- Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.International journal of cancer · 2017Article
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Authors and funding
24 authors.
Funding
Abstract
Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR = 0.52, 95% CI: 0.40-0.68, p for trend = 0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites. The inverse association of vitamin C intake from foods with HNC may reflect a protective effect on these cancers; however, we cannot rule out other explanations.
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