ArticleHuman brain mapping2015
Making sense: Dopamine activates conscious self-monitoring through medial prefrontal cortex.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.Neurobiology of aging · 2020Pooled it
- Rapid improvements and subsequent effects in major depressive disorder patients with somatic pain using rTMS combined with sertraline.Scientific reports · 2023Trial
- Pre-sleep treatment with galantamine stimulates lucid dreaming: A double-blind, placebo-controlled, crossover study.PloS one · 2018Trial
- Methylphenidate and Memory and Attention Adaptation Training for Persistent Cognitive Symptoms after Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness.Current neurology and neuroscience reports · 2024Review
- Neuropsychopharmacological Induction of (Lucid) Dreams: A Narrative Review.Brain sciences · 2024Review
- EngAge - A metacognitive intervention to supplement working memory training: A feasibility study in older adults.Aging brain · 2023Article
- Differential contributions of serotonergic and dopaminergic functional connectivity to the phenomenology of LSD.Psychopharmacology · 2022Article
- Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder.Frontiers in neuroanatomy · 2022Article
- Exploring Clinical Correlates of Metacognition in Bipolar Disorders Using Moderation Analyses: The Role of Antipsychotics.Journal of clinical medicine · 2021Article
- Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction.Frontiers in systems neuroscience · 2020Article
- Attenuation of dopamine-induced GABA release in problem gamblers.Brain and behavior · 2019Article
- Dopamine is a double-edged sword: dopaminergic modulation enhances memory retrieval performance but impairs metacognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Bizarreness of Lucid and Non-lucid Dream: Effects of Metacognition.Frontiers in psychology · 2019Article
- Assessment of Metacognition and Reversal Learning in Parkinson's Disease: Preliminary Results.Frontiers in human neuroscience · 2018Article
- Exogenous dopamine reduces GABA receptor availability in the human brain.Brain and behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self-awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transiently impair self-awareness. Conversely, we hypothesize that dopaminergic stimulation may improve self-awareness and metacognition (i.e., the ability of the brain to consciously monitor its own cognitive processes). Here, we demonstrate improved noetic (conscious) metacognition by oral administration of 100 mg dopamine in minimal self-awareness. In a separate experiment with extended self-awareness dopamine improved the retrieval accuracy of memories of self-judgment (autonoetic, i.e., explicitly self-conscious) metacognition. Concomitantly, magnetoencephalography (MEG) showed increased amplitudes of oscillations (power) preferentially in the medial prefrontal cortex. Given that electromagnetic activity in this region is instrumental in self-awareness, this explains the specific effect of dopamine on explicit self-awareness and autonoetic metacognition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.