ArticleInfection control and hospital epidemiology2015
Postoperative burden of hospital-acquired Clostridium difficile infection.
Article in Infection control and hospital epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis.Infection · 2022Pooled it
- Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections.World journal of gastroenterology · 2016Pooled it
- Association between postoperative Clostridioides difficile infection and outcomes following pancreatoduodenectomy for pancreatic cancer: a national cohort study.Surgical endoscopy · 2026Article
- Risk Factors forThe Annals of otology, rhinology, and laryngology · 2026Article
- [Analysis ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Analysis of risk factors for community-acquiredTranslational pediatrics · 2023Article
- Article
- Robotic pyelolithotomy in a solitary pelvic kidney complicated with fulminant Clostridium difficile: a case report.Journal of medical case reports · 2022Article
- Autoinducing peptide-based quorum signaling systems in Clostridioides difficile.Current opinion in microbiology · 2022Review
- Article
- Long-Term Antibiotic Prophylaxis in Urology and High Incidence ofMicroorganisms · 2020Article
- Consumption of Antibiotics and Epidemiology ofAntibiotics (Basel, Switzerland) · 2020Article
- Review
- Hospital Infection Control:Clinics in colon and rectal surgery · 2020Review
- Article
- Clostridium difficile infection in the USA: incidence and associated factors in revision total knee arthroplasty patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- Impact of a change in duration of prophylactic antibiotics on infectious complications after radical cystectomy with a neobladder.Medicine · 2018Article
- The Impact of Bariatric Surgery on Short Term Risk of Clostridium Difficile Admissions.Obesity surgery · 2018Article
- The Morbidity and Mortality of Laparoscopic Appendectomy in Patients with Cirrhosis.Clinical medicine insights. Gastroenterology · 2018Article
- Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
OBJECTIVE Clostridium difficile infection (CDI) is a common hospital-acquired infection. Previous reports on the incidence, risk factors, and impact of CDI on resources in the surgical population are limited. In this context, we study CDI across diverse surgical settings. METHODS We prospectively identified patients with laboratory-confirmed postoperative CDI after 40 different general, vascular, or gynecologic surgeries at 52 academic and community hospitals between July 2012 and September 2013. We used multivariable regression models to identify CDI risk factors and to determine the impact of CDI on resource utilization. RESULTS Of 35,363 patients, 179 (0.51%) developed postoperative CDI. The highest rates of CDI occurred after lower-extremity amputation (2.6%), followed by bowel resection or repair (0.9%) and gastric or esophageal operations (0.7%). Gynecologic and endocrine operations had the lowest rates (0.1% and 0%, respectively). By multivariable analyses, older age, chronic immunosuppression, hypoalbuminemia (≤3.5 g/dL), and preoperative sepsis were associated with CDI. Use of prophylactic antibiotics was not independently associated with CDI, neither was sex, body mass index (BMI), surgical priority, weight loss, or comorbid conditions. Three procedure groups had higher odds of postoperative CDI: lower-extremity amputations (adjusted odds ratio [aOR], 3.5; P=.03), gastric or esophageal operations (aOR, 2.1; P=.04), and bowel resection or repair (aOR, 2; P=.04). Postoperative CDI was independently associated with increased length of stay (mean, 13.7 d vs 4.5 d), emergency department presentations (18.9 vs 9.1%) and readmissions (38.9% vs 7.2%, all P<.001). CONCLUSIONS Incidence of postoperative CDI varies by surgical procedure. Postoperative CDI is also associated with higher rates of extended length of stay, emergency room presentations, and readmissions, which places a potentially preventable burden on hospital resources.
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